{"id":305,"date":"2019-01-26T18:50:50","date_gmt":"2019-01-26T23:50:50","guid":{"rendered":"http:\/\/elements.chem.umass.edu\/kaltashovlab\/?page_id=305"},"modified":"2024-03-29T13:15:30","modified_gmt":"2024-03-29T17:15:30","slug":"former-post-doctoral-scholars","status":"publish","type":"page","link":"https:\/\/elements.chem.umass.edu\/kaltashovlab\/former-post-doctoral-scholars\/","title":{"rendered":"Former Post-doctoral Scholars"},"content":{"rendered":"<p><strong>Andras Dobo (2000-2002)<\/strong><\/p>\n<p>Project: <em><strong>Protein ion charge state distributions in ESI MS and their correlations with conformations in solution.<br \/>\n<\/strong><\/em><\/p>\n<p>Representative publications:<\/p>\n<ul>\n<li>A. Mohimen, A. Dobo, J.K. Hoerner, I.A. Kaltashov. <a href=\"https:\/\/pubs.acs.org\/doi\/abs\/10.1021\/ac034095%2B\">A chemometric approach to detection and characterization of multiple protein conformers in solution using electrospray ionization mass spectrometry.<\/a> <em>Anal. Chem<\/em>., <strong>2003<\/strong>, <em>75<\/em>, 4139-4147<\/li>\n<li>A. Dobo, I.A. Kaltashov. <a href=\"https:\/\/pubs.acs.org\/doi\/abs\/10.1021\/ac010713f\">Detection of multiple protein conformational ensembles in solution via deconvolution of charge state distributions in ESI MS<\/a>. <em>Anal. Chem<\/em>.,<strong> 2001<\/strong>, <em>73<\/em>, 4763-4773<\/li>\n<\/ul>\n<p>click <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=Dobo+kaltashov\">here<\/a> to see all papers co-authored by Dr. Andras Dobo based on his work at UMass-Amherst<\/p>\n<p>Current position: <em>Sigma-Aldrich-Fluka Europe<\/em><\/p>\n<p style=\"text-align: center\">*****<\/p>\n<p><strong>Rinat R. Abzalimov (2004-2008) <\/strong><\/p>\n<p>Project: <strong><em>Top-down hydrogen\/deuterium exchange; mass spectrometry of highly heterogeneous biomolecules<\/em><\/strong><\/p>\n<p>Representative publications:<\/p>\n<ul>\n<li>G. Wang, R.R. Abzalimov, C. Bobst and I.A. Kaltashov. <a href=\"https:\/\/www.pnas.org\/content\/110\/50\/20087.long\">Conformer-specific characterization of nonnative protein states using hydrogen exchange and top-down mass spectrometry.<\/a>\u00a0<em><span class=\"jrnl\" title=\"Proceedings of the National Academy of Sciences of the United States of America\">Proc. Natl. Acad. Sci. U.S.A<\/span>.<\/em> <strong>2013,<\/strong> 110, 20087-20092<\/li>\n<li>R.R. Abzalimov and I.A. Kaltashov. <a href=\"https:\/\/pubs.acs.org\/doi\/10.1021\/ac101848z\">Electrospray ionization mass spectrometry of highly heterogeneous protein systems: protein ion charge state assignment via incomplete charge reduction<\/a>. <em>Anal. Chem<\/em>., <strong>2010<\/strong>, <em>82<\/em>, 7523-7526<\/li>\n<li>I.A. Kaltashov, R.R. Abzalimov. <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S104403050800456X?via%3Dihub\">Do ionic charges in ESI MS provide useful information on macromolecular structure<\/a>? <em>J. Am. Soc. Mass Spectrom<\/em>., <strong>2008<\/strong>, <em>19<\/em>, 1239-1246<\/li>\n<\/ul>\n<p>click <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=rinat+abzalimov+and+igor+kaltashov\">here<\/a> to see all papers co-authored by Dr. Rinat Abzalimov based on his work at UMass-Amherst<\/p>\n<p><a href=\"http:\/\/structbio.asrc.cuny.edu\/people\/dr-rinat-abzalimov\/\">Current position<\/a>: <em>Director, Biomolecular Mass Spectrometry Facility and Research Assistant Professor, Advanced Science Research Center\u2019s Structural Biology Initiative<\/em><\/p>\n<p style=\"text-align: center\">*****<\/p>\n<p><strong>Cedric Bobst (2008-2012, continued as Research Fellow through 2019)<\/strong><\/p>\n<p>Project: <strong><em>Higher order structure, dynamics and stability of protein-based therapeutics<br \/>\n<\/em><\/strong><\/p>\n<ul>\n<li>C.E. Bobst, J. Sperry, O.V. Friese, I.A. Kaltashov.<sup>*<\/sup> <u>Simultaneous evaluation of a vaccine component microheterogeneity and conformational integrity using native mass spectrometry and limited charge reduction<\/u>. <em>J. Am. Soc. Mass Spectrom<\/em>. <strong>2021<\/strong>, <em>32<\/em>, 1631-1637<\/li>\n<li>C.E. Bobst, and I.A. Kaltashov. <u>Enhancing the quality of H\/D exchange measurements with mass spectrometry detection in disulfide-rich proteins using electron capture dissociation<\/u>. <em>Anal. Chem<\/em><em>. <\/em><strong>2014<\/strong>, <em>86<\/em>, 5225-5531<\/li>\n<li>C.E. Bobst, S. Wang, W.-C. Shen, and I.A. Kaltashov. <u>Mass spectrometry study of a transferrin-based protein drug reveals the key role of protein aggregation for successful oral delivery<\/u>. <em>Proc. Natl. Acad<\/em><em>. Sci. U.S.A.<\/em> <strong>2012<\/strong>, <em>109<\/em>, 13544-13548<\/li>\n<li>C.E. Bobst, J.J. Thomas, P.A. Salinas, P. Savickas, I.A. Kaltashov. <u>Impact of oxidation on protein therapeutics: Conformational dynamics of intact and oxidized acid-\u03b2-glucocerebrosidase at near-physiological pH<\/u>. <em>Protein Sci<\/em><em>.<\/em> <strong>2010<\/strong>, <em>19<\/em>, 2366-2378<\/li>\n<li>C.E. Bobst, M. Zhang, I.A. Kaltashov. <u>Existence of a non-canonical state of iron-bound transferrin at endosomal pH revealed by hydrogen exchange and mass spectrometry<\/u>. <em>J. Mol. Biol<\/em>. <strong>2009<\/strong>, <em>388<\/em>, 954-967<\/li>\n<li>C.E. Bobst, \u00a0R.R. Abzalimov, D. Houde, M. Kloczewiak, R. Mhatre, S.A. Berkowitz, I.A. Kaltashov. <u>Detection and characterization of altered conformations of protein pharmaceuticals using complementary mass spectrometry-based approaches<\/u>. <em>Anal. Chem<\/em>. <strong>2008<\/strong>, <em>80<\/em>, 7473-7481<\/li>\n<\/ul>\n<p>Current position: <em>Associate Director, <a href=\"https:\/\/www.umass.edu\/ials\/mass-spectrometry\">Mass Spectrometry Core Facility, Institute for Applied Life Sciences, UMass-Amherst<\/a><br \/>\n<\/em><\/p>\n<p style=\"text-align: center\">*****<\/p>\n<p><strong>Gregoire Bonvin (2015-2016) <\/strong><\/p>\n<p>Project: <strong><em>Serum transferrin and non-ferrous metal ion transfer<br \/>\n<\/em><\/strong><\/p>\n<p>Representative publications:<\/p>\n<ul>\n<li>G. Bonvin, C.E. Bobst and I.A. Kaltashov. <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S1387380617300398\">Interaction of transferrin with non-cognate metals studied by native electrospray ionization mass spectrometry<\/a>. <em>Int. J. Mass Spectrom<\/em>., <strong>2017<\/strong>, <em>420<\/em>, 74-82<\/li>\n<\/ul>\n<p>Current position: <em>Chemistry Specialist, the State of Geneva, Geneva, Switzerland<br \/>\n<\/em><\/p>\n<p style=\"text-align: center\">*****<\/p>\n<p><strong>Vanda Liadinskaia (2018) <\/strong><\/p>\n<p>Project<em>: <strong>Heparin structure\/bioactivity studies<\/strong><\/em><\/p>\n<p><em>Current position: Senior Researcher at <a href=\"https:\/\/www.pentair.com\/\">Pentair<\/a><br \/>\n<\/em><\/p>\n<p style=\"text-align: center\">*****<\/p>\n<p><strong>Wenhua Yang (2019-2021) <\/strong><\/p>\n<p>Project: <strong><em>Molecular basis of allergy and autoimmunity<br \/>\n<\/em><\/strong><\/p>\n<p>Representative publications:<\/p>\n<ul>\n<li>W. Yang, D.G. Ivanov and I.A. Kaltashov. <u>Extending the capabilities of intact-mass analyses to monoclonal immunoglobulins of the E-isotype (IgE)<\/u>. <em>MAbs <\/em><strong>2022<\/strong>, <em>14<\/em>, 2103906<\/li>\n<li>W. Yang, Z. Tu, D. McClements and I.A. Kaltashov. <u>A systematic assessment of structural heterogeneity and IgG\/IgE-binding of ovalbumin<\/u>. <em>Food Funct<\/em>. <strong>2021<\/strong>, <em>12<\/em>, 8130-8140<\/li>\n<li>W. Yang, Z. Tu, Q. Li, I.A. Kaltashov and D.J. McClements. <u>Utilization of sonication-glycation to improve the functional properties of ovalbumin: A high-resolution mass spectrometry study<\/u>. <em>Food Hydrocolloids<\/em> <strong>2021<\/strong>, <em>119<\/em>, 106822<\/li>\n<\/ul>\n<p>Current position: <em>Associate Professor and Distinguished Scholar<\/em>, <em>Zhongkai University of Agriculture and Engineering (China)<br \/>\n<\/em><\/p>\n<p style=\"text-align: center\">*****<\/p>\n<p><strong>Si-Hung Le (2022) <\/strong><\/p>\n<p>Project: <strong><em>Molecular mechanisms of heparin-induced thrombocytopenia and vaccine-induced immune thrombotic thrombocytopenia<br \/>\n<\/em><\/strong><\/p>\n<p>Representative publications:<\/p>\n<ul>\n<li>D. G. Ivanov, N. Ivetic, Y. Du, S.N. Nguyen, S.H. Le, D. Favre, I. Nazy, and I.A. Kaltashov. <u>Reverse Engineering<\/u><u> of a Pathogenic Antibody Reveals the Molecular Mechanism of Vaccine-Induced Immune Thrombotic Thrombocytopenia<\/u>. <em>J. Am. Chem. Soc<\/em>. <strong>2023<\/strong>, <em>145<\/em>, 25203- 252132<\/li>\n<li>S.N. Nguyen, S.H. Le, D.G. Ivanov, N. Ivetic, I. Nazy, I.A. KaltashovA. <a href=\"https:\/\/www.biorxiv.org\/content\/10.1101\/2023.05.28.542636v1.full\">Structural characterization of a pathogenic antibody underlying vaccine-induced immune thrombotic thrombocytopenia (VITT)<\/a>. <em>Anal. Chem<\/em>., <strong>2024<\/strong>, in press (a pre-print is available at<em> bioRxiv<\/em>: 2023.2005.2028.542636)<\/li>\n<\/ul>\n<p>Current position: <em>Applications Scientist, <\/em><a href=\"https:\/\/www.linkedin.com\/in\/th%C4%83ng-long-instruments-297343283\/\">Th\u0103ng Long Instruments (Hanoi, Vietnam)<\/a><\/p>\n<p style=\"text-align: center\">*****<\/p>\n<p><strong>Son N. Nguyen (2019-2022) <\/strong><\/p>\n<p>Project: <strong><em>Molecular mechanisms of heparin-induced thrombocytopenia and vaccine-induced immune thrombotic thrombocytopenia<br \/>\n<\/em><\/strong><\/p>\n<p>Representative publications:<\/p>\n<ul>\n<li>D. G. Ivanov, N. Ivetic, Y. Du, S.N. Nguyen, S.H. Le, D. Favre, I. Nazy, and I.A. Kaltashov. <u>Reverse Engineering<\/u><u> of a Pathogenic Antibody Reveals the Molecular Mechanism of Vaccine-Induced Immune Thrombotic Thrombocytopenia<\/u>. <em>J. Am. Chem. Soc<\/em>. <strong>2023<\/strong>, <em>145<\/em>, 25203- 252132<\/li>\n<li>S.N. Nguyen, S.H. Le, D.G. Ivanov, N. Ivetic, I. Nazy, I.A. KaltashovA. <a href=\"https:\/\/www.biorxiv.org\/content\/10.1101\/2023.05.28.542636v1.full\">Structural characterization of a pathogenic antibody underlying vaccine-induced immune thrombotic thrombocytopenia (VITT)<\/a>. <em>Anal. Chem<\/em>., <strong>2024<\/strong>, in press (a pre-print is available at<em> bioRxiv<\/em>: 2023.2005.2028.542636)<\/li>\n<\/ul>\n<p>Current position: <em>Senior Research Scientist, <a href=\"https:\/\/www.umassmed.edu\/MSF\/\">Mass Spectrometry Core Facility, UMass Medical School (Worcester, MA)<\/a><br \/>\n<\/em><\/p>\n<p style=\"text-align: center\">*****<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Andras Dobo (2000-2002) Project: Protein ion charge state distributions in ESI MS and their correlations with conformations in solution. Representative publications: A. Mohimen, A. Dobo, J.K. Hoerner, I.A. Kaltashov. A chemometric approach to detection and characterization of multiple protein conformers in solution using electrospray ionization mass spectrometry. Anal. Chem., 2003, 75, 4139-4147 A. Dobo, I.A. &hellip; <a href=\"https:\/\/elements.chem.umass.edu\/kaltashovlab\/former-post-doctoral-scholars\/\" class=\"more-link\">Continue reading <span class=\"screen-reader-text\">Former Post-doctoral Scholars<\/span><\/a><\/p>\n","protected":false},"author":69,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-305","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/elements.chem.umass.edu\/kaltashovlab\/wp-json\/wp\/v2\/pages\/305","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/elements.chem.umass.edu\/kaltashovlab\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/elements.chem.umass.edu\/kaltashovlab\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/elements.chem.umass.edu\/kaltashovlab\/wp-json\/wp\/v2\/users\/69"}],"replies":[{"embeddable":true,"href":"https:\/\/elements.chem.umass.edu\/kaltashovlab\/wp-json\/wp\/v2\/comments?post=305"}],"version-history":[{"count":29,"href":"https:\/\/elements.chem.umass.edu\/kaltashovlab\/wp-json\/wp\/v2\/pages\/305\/revisions"}],"predecessor-version":[{"id":1499,"href":"https:\/\/elements.chem.umass.edu\/kaltashovlab\/wp-json\/wp\/v2\/pages\/305\/revisions\/1499"}],"wp:attachment":[{"href":"https:\/\/elements.chem.umass.edu\/kaltashovlab\/wp-json\/wp\/v2\/media?parent=305"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}