{"id":361,"date":"2016-04-07T02:38:07","date_gmt":"2016-04-07T02:38:07","guid":{"rendered":"http:\/\/elements.chem.umass.edu\/knappgroup\/?page_id=361"},"modified":"2016-09-15T17:51:56","modified_gmt":"2016-09-15T17:51:56","slug":"hypoxia","status":"publish","type":"page","link":"https:\/\/elements.chem.umass.edu\/knappgroup\/hypoxia\/","title":{"rendered":"Hypoxia"},"content":{"rendered":"

\"hif_action13\"<\/a><\/p>\n

The response to low [O2<\/sub>] (hypoxia) is crucial for cellular growth, proliferation, and proliferative disease states. My group focuses on the HIF hydroxylases, FIH and PHD, which are human O2-sensing enzymes that hydroxylate specific protein residues on the HIF transcription factor.<\/p>\n

\"ros\"<\/a><\/p>\n

These HIF-hydroxylases are nonheme Fe, \u03b1KG-dependent oxygenases, but their unique role leads to interesting mechanisms, including inactivation pathways involving ROS release or autohydroxylation.<\/p>\n

 <\/p>\n

\"stereoisomers\"<\/a><\/p>\n

In addition to mechanistic studies to identify reactivities and new substrate, we are looking at the HIF hydroxylases as engineering templates to redesign the active site for new chemistry.<\/p>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

The response to low [O2] (hypoxia) is crucial for cellular growth, proliferation, and proliferative disease states. My group focuses on the HIF hydroxylases, FIH and PHD, which are human O2-sensing enzymes that hydroxylate specific protein residues on the HIF transcription factor. These HIF-hydroxylases are nonheme Fe, \u03b1KG-dependent oxygenases, but their unique role leads to interesting […]<\/p>\n","protected":false},"author":44,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-361","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/elements.chem.umass.edu\/knappgroup\/wp-json\/wp\/v2\/pages\/361","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/elements.chem.umass.edu\/knappgroup\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/elements.chem.umass.edu\/knappgroup\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/elements.chem.umass.edu\/knappgroup\/wp-json\/wp\/v2\/users\/44"}],"replies":[{"embeddable":true,"href":"https:\/\/elements.chem.umass.edu\/knappgroup\/wp-json\/wp\/v2\/comments?post=361"}],"version-history":[{"count":6,"href":"https:\/\/elements.chem.umass.edu\/knappgroup\/wp-json\/wp\/v2\/pages\/361\/revisions"}],"predecessor-version":[{"id":426,"href":"https:\/\/elements.chem.umass.edu\/knappgroup\/wp-json\/wp\/v2\/pages\/361\/revisions\/426"}],"wp:attachment":[{"href":"https:\/\/elements.chem.umass.edu\/knappgroup\/wp-json\/wp\/v2\/media?parent=361"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}