{"id":5152,"date":"2024-06-02T11:01:50","date_gmt":"2024-06-02T16:01:50","guid":{"rendered":"https:\/\/elements.chem.umass.edu\/thaigroup\/?page_id=5152"},"modified":"2024-06-04T20:21:37","modified_gmt":"2024-06-05T01:21:37","slug":"targeted-delivery","status":"publish","type":"page","link":"https:\/\/elements.chem.umass.edu\/thaigroup\/publications\/targeted-delivery\/","title":{"rendered":"Targeted Delivery"},"content":{"rendered":"
305)<\/a>

Gong, S.*; Qiu, J.*; Huang, F.*; Krishna, J.; Alp, Y.; Strieter, E.; Thayumanavan, S. Incorporation of Functional Proteins on Cellular Surfaces via Artificial Cell-Derived Vesicles (ACDVs) for Plasma Membrane Reprogramming. Journal of the American Chemical Society, <\/i>2026<\/a><\/p>\n

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303)<\/a>

Qiu, J.*; Alp, Y.* Gong, S.; Szipszky, P.; Jerry, D. J. & Thayumanavan, S. “HER2 Antibody\u2013Nanogel Conjugates: A High-Capacity, Antibody-Sparing Alternative to Antibody\u2013Drug Conjugates.” Nano Lett. 2025<\/a>\"\"<\/p>\n<\/div><\/div>

299)<\/a>

Das, R; Medeiros, J; Krishna, J; Munugoti, S; Dutta, R; Devarajan, A; Ghosh, A; & Thayumanavan, S; “Multicheckpoint Cellular Targeting of siRNAs Using Antibody-Directed Lipid-Polymer Hybrid Nanoparticles.” Bioconjugate Chemistry. 2025 Jul 3<\/a>.<\/p>\n

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297)<\/a>

Qiu, J; Gong, S; Alp, Y; Medeiros, J; Agnello, E; and Thayumanavan, S “Membrane Fusion Drives Facile Uptake of Cell Membrane-Coated Nanocarriers.” ACS nano<\/i> (2025)<\/a><\/p>\n

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294)<\/a>

Liu, B.*, Gong, S.*, Qiu, J., Ejaz, W., & Thayumanavan, S.\u00a0 “Synergistic Effects of Polycationic and Polyfluorinated Functionalities for Efficient Intracellular Protein Delivery.”\u00a0 Biomacromolecules, 2025<\/a> (https:\/\/doi.org\/10.1021\/acs.biomac.4c01795)<\/i><\/p>\n

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293)<\/a>

Wang, M.*; Prachyathipsakul, T.*; Wisniewski, C. A.; Xiong, C.; Goel, S.; Goel, H.L.; Karner, E.R.;\u00a0 Mukhopadhyay, D.; Gupta, P.; Majee, A.; Thayumanavan, S. and Mercurio, A.M. “Therapeutic induction of ferroptosis in tumors using PD-L1 targeting antibody nanogel conjugates” Cell Chemical Biology, 2024<\/a> (https:\/\/doi.org\/10.1016\/j.chembiol.2024.10.014)<\/p>\n

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290)<\/a>

Gong, S.*; <\/span>Liu, B.*;<\/span> Qiu, J.;<\/span> Huang, F. and<\/span> Thayumanavan S.<\/span>\u00a0“Antibody-Directing Antibody Conjugates (ADACs) Enabled by Orthogonal Click Chemistry for Targeted Intracellular Delivery<\/span>. ”\u00a0Small<\/i>\u00a02024<\/span>, 2402874<\/a>. (https:\/\/doi.org\/10.1002\/smll.202402874)<\/p>\n

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284)<\/a>

Kanjilal, P.; Singh, K.;<\/span> Das, R.; Matte, J. <\/span>and Thayumanavan, S. “Antibody Polymer Conjugates (APCs) for Active Targeted Therapeutic Delivery” <\/span>Biomacromolecules<\/i>\u00a02023<\/span>, 24<\/span>, 8<\/span>, 3638\u20133646,<\/span><\/span><\/a> (DOI:10.1021\/acs.biomac.3c00385)<\/span><\/p>\n

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282)<\/a>

Wu, P.; Prachyathipsakul, T.;<\/span> Huynh, <\/span>U.;<\/span> Qiu, J.; Jerry, D. J. and Thayumanavan, S. “Optimizing Conjugation Chemistry, Antibody Conjugation Site, and Surface Density in Antibody\u2013Nanogel Conjugates (ANCs) for Cell-Specific Drug Delivery”<\/span>\u00a0<\/span>Bioconjugate Chem. <\/i>2023<\/span>, 34<\/span>, 4<\/span>, 707-718,<\/span><\/span><\/a> (DOI:10.1021\/acs.bioconjchem.3c00034)<\/span><\/p>\n

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280)<\/a>

Huynh, U.; Wu, P.; Qiu, J.; Prachyathipsakul, T.; Singh, K.; Jerry, D.J.; Gao, J. and <\/span><\/span>Thayumanavan, S<\/span>. \u201cTargeted Drug Delivery Using a Plug-to-Direct Antibody\u2013Nanogel Conjugate\u201d<\/span><\/span> Biomacromolecules<\/em> 2023, 24, 849\u2212857,<\/a> (DOI:10.1021\/acs.biomac.2c01269)\"\"<\/p>\n<\/div><\/div>

261)<\/a>

Dutta, K.; Das, R.; Medeiros, J.; Kanjilal, K.; Thayumanavan, S.\u201cCharge-Conversion Strategies for Nucleic Acid Delivery\u201d Adv. Funct. Mater., <\/em>2021<\/strong>, 31<\/em>, 2011103<\/a>. (DOI:10.1002\/adfm.202011103)
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259)<\/a>

Liu, B.; Singh, K.; Gong, S.; Canakci, M.; Osborne, B.A.; Thayumanavan, S. \u201cProtein-Antibody Conjugates (PACs): A Plug-and-Play Strategy for Covalent Conjugation and Targeted Intracellular Delivery of Pristine Proteins\u201d Angew. Chemie. Int. Ed., <\/em>2021<\/strong> , 60<\/em>, 12813-12818\u00a0<\/a>. (DOI:10.1002\/anie.202103106)
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257)<\/a>

Dutta, K.; Das, R.; Medeiros, J. M.; Thayumanavan, S. \u201c”Disulfide Bridging Strategies in Viral and Non-viral Platforms for Nucleic Acid Delivery\u201d Biochemistry, <\/em>2021<\/strong>, <\/em>60<\/span>, 13<\/span>, 966\u2013990<\/span><\/em><\/a>. (DOI:10.1021\/acs.biochem.0c00860)
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250)<\/a>

Gao, J.; Dutta, K.; Zhuang, J.; Thayumanavan, S. \u201cCellular and subcellular targeted delivery using a simple all-in-one polymeric nanoassembly” Angew. Chem. Int. Ed., <\/em>2020<\/strong>, 59, <\/em> 23466-23470 <\/a>. (DOI: 10.1002\/anie.202008272)
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