{"id":5329,"date":"2025-05-13T12:50:41","date_gmt":"2025-05-13T17:50:41","guid":{"rendered":"https:\/\/elements.chem.umass.edu\/thaigroup\/?page_id=5329"},"modified":"2025-05-17T22:05:02","modified_gmt":"2025-05-18T03:05:02","slug":"target-protein-degradation","status":"publish","type":"page","link":"https:\/\/elements.chem.umass.edu\/thaigroup\/publications\/target-protein-degradation\/","title":{"rendered":"Target Protein Degradation"},"content":{"rendered":"
304)<\/a>

Lu, R. H. H.*, Krishna, J.*, Alp, Y., & Thayumanavan, S. Polymeric Lysosome-Targeting Chimeras (PolyTACs): Extracellular Targeted Protein Degradation without Co-Opting Lysosome-Targeting Receptors. Journal of the American Chemical Society<\/i>. 2026<\/a><\/p>\n

\"\"<\/p>\n<\/div><\/div>

296)<\/a>

Dutta, R.*; Alp, Y.*; Gupta, P.*; Singh, B.*, & Thayumanavan, S. “Multivalent Ligand-Protein Interactions Using Polymeric Lysosome-Targeting Chimeras (PolyTACs) Leads to Lysosome-Targeting Receptor-Independent Degradation of Transmembrane Proteins.” bioRxiv<\/i>,<\/a> 2025-05.<\/p>\n

\"\"<\/p>\n

 <\/p>\n<\/div><\/div>

295)<\/a>
Dutta, R. *; Devarajan, A.*; Talluri, A.; Das, R.; and Thayumanavan, S.; “Dual-Action-Only PROTACs” Journal of the American Chemical Society, 2025<\/a>(<\/cite>10.1021\/jacs.5c00131)<\/span><\/div>\n
\"Figure<\/div>\n<\/div><\/div>
292)<\/a>

Lu, H.H.*; <\/span><\/span>Krishna<\/span><\/span>, J*; Alp, Y;<\/span><\/span>\u00a0Thayumanavan S.” <\/span><\/span>Polymeric Lysosomal-Targeting Chimeras: Extracellular Targeted Protein Degradation Without Co-opting Lysosome-Targeting Receptors” BioRxiv<\/a>, (https:\/\/doi.org\/10.1101\/2024.09.18.613672)<\/p>\n<\/div><\/div><\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":109,"featured_media":0,"parent":5,"menu_order":6,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-5329","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/elements.chem.umass.edu\/thaigroup\/wp-json\/wp\/v2\/pages\/5329","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/elements.chem.umass.edu\/thaigroup\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/elements.chem.umass.edu\/thaigroup\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/elements.chem.umass.edu\/thaigroup\/wp-json\/wp\/v2\/users\/109"}],"replies":[{"embeddable":true,"href":"https:\/\/elements.chem.umass.edu\/thaigroup\/wp-json\/wp\/v2\/comments?post=5329"}],"version-history":[{"count":3,"href":"https:\/\/elements.chem.umass.edu\/thaigroup\/wp-json\/wp\/v2\/pages\/5329\/revisions"}],"predecessor-version":[{"id":5335,"href":"https:\/\/elements.chem.umass.edu\/thaigroup\/wp-json\/wp\/v2\/pages\/5329\/revisions\/5335"}],"up":[{"embeddable":true,"href":"https:\/\/elements.chem.umass.edu\/thaigroup\/wp-json\/wp\/v2\/pages\/5"}],"wp:attachment":[{"href":"https:\/\/elements.chem.umass.edu\/thaigroup\/wp-json\/wp\/v2\/media?parent=5329"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}