{"id":14,"date":"2016-03-25T14:06:38","date_gmt":"2016-03-25T14:06:38","guid":{"rendered":"http:\/\/elements.chem.umass.edu\/youlab\/?page_id=14"},"modified":"2026-04-26T19:15:46","modified_gmt":"2026-04-26T23:15:46","slug":"publications","status":"publish","type":"page","link":"https:\/\/elements.chem.umass.edu\/youlab\/publications\/","title":{"rendered":"Publications"},"content":{"rendered":"
\n

Publications at\u00a0UMass<\/h3>\n

(* Corresponding author;\u00a0 #<\/sup> Co-first author;\u00a0 \u00a0^ Undergraduate author)<\/strong><\/p>\n

2026<\/h4>\n

[106]\u00a0 A. Hecht#<\/sup>, Q. Yu#<\/sup>, & M. You*. (2026) “Rational development of fluorogenic RNA sensors for live-cell imaging”. \u00a0RNA Scaffolds: Methods and Protocols, 3rd Edition<\/em><\/a>, submitted.\u00a0 [Invited book chapter in Methods in Molecular Biology <\/i>book series, <\/i>Springer]<\/p>\n

[105]\u00a0 Z. Xue, O. Mukherjee, L, Mi, Y. Guo, R. Zheng, C. Yuan^, & M. You*. (2026) “Programmable and switchable RNA scaffolds for synthetic condensate engineering in mammalian cells”.\u00a0 Submitted.\u00a0 [Preprint on bioRxiv<\/a>].<\/p>\n

[104]\u00a0 P. Bhattacharyya, M. M. R. Singuru, R. Banerjee, P. Le^, Q. Tian,\u00a0 & M. You*. (2026) “Force-locking DNA hairpin probe for high-throughput and cumulative detection of intercellular molecular tensions”.\u00a0 Submitted.<\/p>\n

[103]\u00a0 Z. Liu*, & M. You. (2026) “DNA-based nanostructures: advancing drug delivery and disease therapy”.\u00a0 Adv Drug Deliv Rev<\/em><\/a>, <\/span>in press\u00a0 [Invited Perspective]<\/p>\n

[102]\u00a0 M. M. R. Singuru*, P. Bhattacharyya, & M. You*. (2026) “Mechanically triggered DNA Nanovehicles for targeted dual-drug cancer therapy”.\u00a0 Adv Sci<\/em><\/a>, <\/span>in press.\u00a0\"\"<\/a><\/p>\n

2025<\/h4>\n

[101]\u00a0 L. Mi#<\/sup>, S. Khajouei#<\/sup>, & M. You*. (2025) “Multiplexed RNA imaging and in situ profiling in living cells”.\u00a0 Chem Sci<\/em><\/a>, <\/span>16, 21152-21173\u00a0 [Invited Review for 15th Anniversary: Chemical Science Leading Investigators collection<\/a>;\u00a0 Also as Most popular 2025 analytical chemistry articles<\/a>; preprint on Chem<\/a>Rxiv<\/a>]<\/p>\n

[100]\u00a0 Z. Xue, O. Mukherjee, & M. You*. (2025) “Uncovering RNA grammar in driving synthetic condensates”.\u00a0 Trends in Chemistry<\/em><\/a>, <\/span>7, 814-826.\u00a0 [Invited Review for the special issue of Chemistry of Nucleic Acids<\/em>]<\/p>\n

[99]\u00a0 M. M. R. Singuru*, P. Bhattacharyya, H. P. Sriramakrishnan, & M. You*. (2025) “Sensitive detection of intercellular tensile forces via Cas12a-assisted membrane molecular probes”.\u00a0 Nano Letters<\/em><\/a>, <\/span>25<\/span>, <\/span>13519\u201313525.<\/span>\"\"<\/a><\/p>\n

[98]\u00a0 L. Mi, & M. You*. (2025) “Genetically encoded fluorogenic RNA-based bioluminescence resonance energy transfer (BRET) sensors for cellular imaging and target detection”.\u00a0 SLAS Discovery<\/em><\/a><\/span>, 35, 100243.\u00a0 [Invited research paper as part of a SLAS Graduate Fellowship awarded to L. Mi]<\/p>\n

[97]\u00a0 M. M. R. Singuru*, M. A. Tabrizi, P. Bhattacharyya, A. A. Ali, & M. You*. (2025) “Force-responsive delivery of anticancer drugs via a DNA mechanical nanovehicle”. \u00a0Nano Letters<\/em><\/a><\/span>, 25<\/span>, <\/span>336-342.<\/span>\"\"<\/a><\/p>\n

[96]\u00a0 M. A. Tabrizi*, A. A. Ali, M. M. R. Singuru, L, Mi, P. Bhattacharyya, & M. You*. (2025) “A portable and sensitive DNA-based electrochemical sensor for detecting piconewton-scale cellular forces”. \u00a0Anal. Chim. Acta<\/em><\/a><\/span>, 1333, 343392 [Preprint on bioRxiv<\/a>]\"\"<\/a><\/p>\n

2024<\/h4>\n

[95]\u00a0 R. Zheng#<\/sup>, Z. Xue#<\/sup>, & M. You*. (2024) “Optogenetic tools for regulating RNA metabolism and functions”. \u00a0ChemBioChem<\/em><\/a><\/span>, 25, e202400615.\u00a0 [Invited Review]<\/p>\n

[94]\u00a0 A. A. Ali, & M. You*. (2024) “DNA-modulated dimerization and oligomerization of cell membrane receptors”. \u00a0Chem Comm<\/em><\/a><\/span>, 60, 10265-10279.\u00a0 [Invited Review]<\/p>\n

[93]\u00a0 X. Wang, C. Zhao, X. Wang, Z. Li, Y. Shu*, J. Wang*, & M. You*. (2024) “Synthesis of fluorescent AuNCs with RNA as template”. \u00a0Colloids Surf. B Biointerfaces<\/a>, <\/em>241, 114056.<\/em>\"\"<\/a>[92]\u00a0 P. Bhattacharyya#<\/sup>, Q. Tian#<\/sup>, & M. You*. (2025) “Method for imaging and quantifying molecular tensions at cell-cell junctions using DNA-based fluorescent probes”, in DNA Nanotechnology: Methods and Protocols<\/a><\/em> book series, Springer (invited book chapter).<\/p>\n

[91]\u00a0 R. Zheng#<\/sup>, R. Wu#<\/sup>*, Y. Liu, Z. Sun, Z. Xue, Y. Bagheri, S. Khajouei, L. Mi, Q. Tian, R. Pho^, Q. Liu^, S. Siddiqui^, K. Ren*, & M. You*. (2024) “Multiplexed sequential imaging in living cells with orthogonal fluorogenic RNA aptamer\/dye pairs”. \u00a0Nucleic Acids Research<\/em><\/a>, 52, e67. \u00a0[Preprint on bioRxiv<\/a>] \"\"<\/a><\/p>\n

[90]\u00a0 A. A. Ali, M. A. Tabrizi, & M. You*. (2024) “Forced rewiring of RTK signaling”. Nature Chemical Biology<\/em><\/a>, 20, 946-947.\u00a0 [Invited News & Views]<\/p>\n

[89]\u00a0 M. A. Tabrizi*, P. Bhattacharyya, R. Zheng, & M. You*. (2024) “Electrochemical DNA-based sensors for measuring cell-generated forces”. Biosens Bioelectron<\/em><\/a>, 253, 116185\u00a0 [Preprint on bioRxiv<\/a>]\"\"<\/a><\/p>\n

2023<\/h4>\n

[88]\u00a0 Q. Tian, F. Yang, H. Jiang, P. Bhattacharyya, T. Xie, A. A. Ali, Y. Sun*, & M. You*. (2023) “Imaging and detecting intercellular tensile forces in spheroids and embryoid bodies using lipid-modified DNA probes”. \u00a0Front Cell Dev Biol<\/em><\/a><\/span>, 11, 1220079.\"\"<\/a><\/p>\n

[87]\u00a0 Z. Xue#<\/sup>, K. Ren#<\/sup>*, R. Wu, Z. Sun, R. Zheng, Q. Tian, A. A. Ali, L. Mi, & M. You*. (2023) “Targeted RNA condensation in living cells via genetically encoded triplet repeat tags”. \u00a0Nucleic Acids Res<\/em><\/a><\/span>, 51, 8337-8347. [Preprint on bioRxiv<\/a>]
\n\"\"<\/a><\/p>\n

[86]\u00a0 L. Mi#<\/sup>, Q. Yu#<\/sup>, A.P.K.K. Karunanayake Mudiyanselage, R. Wu, Z. Sun, R. Zheng, K. Ren*, & M. You*. (2023) “Genetically encoded RNA-based bioluminescence resonance energy transfer (BRET) sensors”.\u00a0 ACS Sensors<\/em><\/a>, 8, 308-316. \u00a0[Preprint on bioRxiv<\/a>]\"\"<\/a><\/p>\n

[85]\u00a0 L. Zhu, Y. Shen, S. Deng, Y. Wan, J. Luo, Y. Su, M. You, C. Fan, & K. Ren*. (2023) “Controllable mitochondrial aggregation and fusion by a programmable DNA binder”. \u00a0Chem Sci<\/em><\/a><\/span>, 14, 8084-8094.\u00a0 [Preprint on Research Square<\/a>]<\/p>\n

2022<\/h4>\n

[84]\u00a0 A. A. Ali, Y. Bagheri*, Q. Tian, & M. You*. (2022) “Advanced DNA Zipper probes for detecting cell membrane lipid domains”. \u00a0Nano Letters<\/em><\/a>, 22, 7579-7587.\"\"<\/a><\/p>\n

[83]\u00a0 A. A. Ali#<\/sup>, Y. Bagheri#<\/sup>, & M. You*. (2022) “Digging into the biophysical features of cell membranes with lipid-DNA conjugates”.\u00a0 Quarterly Rev Biophys<\/em><\/a>, 55, E5.\u00a0 [Invited contribution]<\/p>\n

[82]\u00a0 B. Zhao*, & M. You*. (2022) “DNA nanotechnology on bio-membranes”.\u00a0 Membranes<\/a>, <\/em>12, 491.\u00a0 [Editorial for the special issue of DNA Nanotechnology on Bio-Membranes<\/em>]<\/p>\n

[81]\u00a0 Q. Tian#<\/sup>, P. Keshri#<\/sup>, & M. You*. (2022) “Recent developments in DNA-based mechanical nanodevices”.\u00a0 Chem Commun<\/a>, <\/em>58, 4700-4710.\u00a0 [Invited contribution in the special issue of Emerging Investigators<\/em>]<\/p>\n

[80]\u00a0 A.P.K.K. Karunanayake Mudiyanselage, & M. You*. (2022) “A catalytic hairpin assembly-based approach for RNA imaging in living cells”.\u00a0 Live-Cell RNA Imaging-Methods and Protocols<\/em><\/a>.\u00a0 [Invited book chapter in Methods in Molecular Biology <\/i>book series, <\/i>Springer]<\/p>\n

[79]\u00a0 Y. Bagheri#<\/sup>, A. A. Ali#<\/sup>, P. Keshri, J. Chambers, A. Gershenson*, & M. You*. (2022) “Imaging membrane order and dynamic interactions in living cells with a DNA Zipper probe”. Angew Chem Int Ed<\/a><\/em>, 61, e202112033.\u00a0 [Also in Hot Topic: Membranes<\/a>]\"\"<\/a><\/p>\n

2021<\/h4>\n

[78]\u00a0 Z. Sun, R. Wu, B. Zhao, P. Chien*, & M. You*. (2021) “Live-cell imaging of guanosine tetra- and pentaphosphate (p)ppGpp with RNA-based fluorescent sensors”.\u00a0 Angew Chem Int Ed<\/a><\/em>, 60, 24040-24047.\u00a0 [Preprint on bioRxiv<\/a>]\"\"<\/a><\/p>\n

[77]\u00a0 R. Wu, R. Zheng, & M. You*. (2021) “ROAD paved for the custom design of genetically encoded RNA nanodevices”.\u00a0 Trends in Chemistry<\/a><\/em>, 3, 691-693.\u00a0 [Invited Spotlight]<\/p>\n

[76]\u00a0 Z. Xiong#<\/sup>, K. Ren#<\/sup>, M. Donnelly, M. You*, & G. Xu*. (2021) “Spectrally filtered photodiode pairs for on-chip ratiometric aptasensing of cytokine dynamics”.\u00a0 Sensors Actuators B: Chem<\/em><\/a>, 345, 130330.<\/p>\n

[75]\u00a0 Q. Yu, R. Zheng, M. Narayanan, & M. You*. (2021) “Rational design of allosteric fluorogenic RNA sensors for cellular imaging”. \u00a0RNA Scaffolds<\/em><\/a>, 141-152.\u00a0 [Invited book chapter in Methods in Molecular Biology <\/i>book series, <\/i>Springer]<\/p>\n

[74]\u00a0 P. Keshri#<\/sup>, B. Zhao#<\/sup>*, T. Xie, Y. Bagheri, J. Chambers, Y. Sun, & M. You*. (2021) “Quantitative and multiplexed fluorescence lifetime imaging of intercellular tensile forces”.\u00a0 Angew Chem Int Ed<\/a><\/em>, 60, 15548-15555.\u00a0 [recognized as a Very Important Paper<\/em>]\"\"<\/a><\/p>\n

[73]\u00a0 Q. Yu#<\/sup>, K. Ren#<\/sup>, & M. You*. (2021) “Genetically encoded RNA nanodevices for cellular imaging and regulation”.\u00a0 Nanoscale<\/em><\/a>, 13, 7988-8003.\u00a0 [Invited contribution in the special issue of Emerging Investigators<\/em>]<\/p>\n

[72]\u00a0 Q. Tian, Y. Bagheri, P. Keshri, R. Wu, K. Ren, Q. Yu, B. Zhao, & M. You*. (2021) “Efficient and selective DNA modification on bacterial membranes”. \u00a0Chem Sci<\/em><\/a>, 12, 2629-2634.\"\"<\/a><\/p>\n

2020<\/h4>\n

[71]\u00a0 Y. Bagheri#<\/sup>, A. A. Ali#<\/sup>, & M. You*. (2020) “Current methods for detecting cell membrane transient interactions”.\u00a0 Front Chem<\/em><\/a>, 8, 603259.\u00a0 [Invited contribution in the special issue of Rising Stars<\/em>]<\/p>\n

[70]\u00a0 K. Ren, P. Keshri, R. Wu, Z. Sun, Q. Yu, Q. Tian, B. Zhao, Y. Bagheri, Y. Xie^, & M. You*. (2020) “A genetically encoded RNA photosensitizer for targeted cell regulation”.\u00a0 Angew Chem Int Ed<\/a><\/em>, 59, 218986-21990.\"\"<\/a><\/p>\n

[69] \u00a0B. Zhao, N. Li, T. Xie, Y. Bagheri, C. Liang, P. Keshri, Y. Sun*, & M. You*. (2020) “Quantifying tensile forces at cell-cell junctions with a DNA-based fluorescent probe”.\u00a0 Chem Sci<\/em><\/a>, 11, 8558-8566.\u00a0 [Preprint on bioRxiv<\/a>]\"\"<\/a><\/p>\n

[68]\u00a0 F. Shafiei, K. McAuliffe^, Y. Bagheri, Z. Sun, Q. Yu, R. Wu*, & M. You*. (2020) “Paper-based fluorogenic RNA aptamer sensors for label-free detection of small molecules”. \u00a0Anal Methods<\/em><\/a>, 12, 2674-2681.\u00a0 <\/em>[Invited contribution in the special issue of Emerging Investigators<\/em>]<\/p>\n

[67] \u00a0R. Wu, A.P.K.K. Karunanayake Mudiyanselage, K. Ren, Z. Sun, Q. Tian, B. Zhao, Y. Bagheri, D. Lutati^, P. Keshri, & M. You*. (2020) “Ratiometric fluorogenic RNA-based sensors for imaging live-cell dynamics of small molecules”.\u00a0 ACS Applied Bio Materials<\/em><\/a>, 3, 2633-2642.\u00a0 <\/em>[Invited contribution in the special issue of Nucleic Acids: Chemistry, Nanotechnology, and Bioapplications<\/em>]<\/p>\n

[66]\u00a0 K. Ren, R. Wu, A.P.K.K. Karunanayake Mudiyanselage, Q. Yu, B. Zhao, Y. Xie^, Y. Bagheri, Q. Tian, & M. You*. (2020) “In situ genetically cascaded amplification for imaging RNA subcellular locations”.\u00a0 J Am Chem Soc<\/em><\/a>, 142, 2968-2974.<\/i>\"\"<\/a><\/p>\n

[65]\u00a0 B. Zhao, Q. Tian, Y. Bagheri, & M. You*. (2020) “Lipid-oligonucleotide conjugates for simple and efficient cell membrane engineering and bioanalysis”.\u00a0 Curr Opin Biomed Eng<\/a><\/em>, <\/i>13, 76-83.\u00a0 \u00a0<\/i>[Invited contribution in the special issue of B<\/em>iomaterials: Biosensors<\/em>]<\/p>\n

2019<\/h4>\n

[64] \u00a0Y. Bagheri, S. Chedid^, F. Shafiei, B. Zhao*, & M. You*. (2019) “Quantitative assessment of the dynamic modification of lipid-DNA probes on live cell membranes”.\u00a0 Chem Sci<\/em><\/a>, 10, 11030-11040.\u00a0 \u00a0[2019 Chemical Science HOT Article]\"\"<\/a><\/p>\n

[63] \u00a0R. Wu, A.P.K.K. Karunanayake Mudiyanselage, F. Shafiei, B. Zhao, Y. Bagheri, Q. Yu, K. McAuliffe^, K. Ren, & M. You*. (2019) “Genetically encoded ratiometric RNA-based sensors for quantitative imaging of small molecules in living cells”. \u00a0Angew Chem Int Ed<\/a><\/em>, 58, 18271-18275.\"\"<\/a><\/p>\n

[62] \u00a0Y. Bagheri#<\/sup>, F. Shafiei#<\/sup>, S. Chedid^, B. Zhao, & M. You*. (2019) “Lipid-DNA conjugates for cell membrane modification, analysis, and regulation”.\u00a0 Supramol Chem<\/a>, <\/em>31, 532-544.\u00a0 \u00a0[Invited contribution in the special issue of Emerging Supramolecular Chemists in North America<\/em>]<\/p>\n

[61]\u00a0 A.F. Smith#<\/sup>, B. Zhao#<\/sup>, M. You, & J.M. Jimenez*. (2019) “Microfluidic DNA-based potassium nanosensors for improved dialysis treatment”. \u00a0Biomed Eng OnLine<\/a>, <\/em>18, 73.<\/em><\/p>\n

[60] \u00a0Z. Sun, T. Nguyen^, K. McAuliffe^, & M. You*. (2019) “Intracellular imaging with genetically encoded RNA-based molecular sensors”.\u00a0 Nanomaterials<\/a>, <\/em>9, 233.\u00a0 \u00a0[Invited contribution in the special issue of Nucleic Acid Architectures for Therapeutics, Diagnostics, Devices and Materials<\/em>]<\/p>\n

[59] \u00a0A.P.K.K. Karunanayake Mudiyanselage, R. Wu, M.A. Leon-Duque^, K. Ren, & M. You*. (2019) “Second-generation fluorogenic RNA-based sensors”.\u00a0 Methods<\/a>, <\/em>161, 24-34.\u00a0 \u00a0[Invited contribution in the special issue of Development and Engineering of Artificial RNAs<\/em>]<\/p>\n

[58] \u00a0M. You*, J.L. Litke,\u00a0<\/span>R. Wu, & S.R. Jaffrey*. (2019) “Detection of low-abundance metabolites in live cells using an RNA integrator”. \u00a0Cell Chem Biol<\/a>, <\/em>26, 471-481.\u00a0 \u00a0[See also Cell Chem Biol Preview<\/a><\/em><\/span>]\"\"<\/a><\/p>\n

[57] \u00a0Q. Yu#<\/sup>, J. Shi#<\/sup>, A.P.K.K. Karunanayake Mudiyanselage, R. Wu, B. Zhao, M. Zhou* & M. You*. (2019) “Genetically encoded RNA sensors for intracellular imaging of silver ions”.\u00a0 Chem Commun<\/a>, <\/em>55, 707-710.\"\"<\/a><\/p>\n

2018<\/h4>\n

[56] \u00a0A.P.K.K. Karunanayake Mudiyanselage, Q. Yu, M.A. Leon-Duque^, B. Zhao, R. Wu & M. You*. (2018) “Genetically encoded catalytic hairpin assembly for sensitive RNA imaging in live cells”.\u00a0 J Am Chem Soc<\/em><\/a>, 140, 8739-8745.\"\"<\/a><\/p>\n

[55]\u00a0\u00a0<\/strong>Wu, T. Zhang, D. Han, H. Fan, G. Zhu, X. Ding, C. Wu, M. You, L. Qiu, J. Li, L. Zhang, X. Lian, R. Hu, Y. Mu, J. Zhou & W. Tan. (2018) “Aligner-mediated cleavage of nucleic acids and its application to isothermal exponential amplification”.\u00a0 Chem Sci<\/em><\/a>, 9, 3050-3055.<\/p>\n

2017<\/h4>\n

[54]\u00a0 <\/strong>B. Zhao, C. O\u2019Brien^, A.P.K.K. Karunanayake Mudiyanselage, N. Li, Y. Bagheri, R. Wu, Y. Sun & M. You*. (2017) “Visualizing intercellular tensile forces by DNA-based membrane molecular probes”.\u00a0 J Am Chem Soc<\/em><\/a>, 139, 18182-18185.\"\"<\/a><\/p>\n

[53] \u00a0M. You#<\/sup>*<\/strong>, Y. Lyu#<\/sup>, D. Han#<\/sup>, L. Qiu, Q. Liu, T. Chen, C. Wu, L. Peng, L. Zhang, G. Bao & W. Tan*. (2017) “DNA probes for monitoring dynamic and transient molecular encounters on live cell membranes”. \u00a0Nature Nanotechnology<\/em><\/a>, 12, 453-459.\u00a0 \u00a0[See also Nat Nano\u00a0News and Views<\/a><\/em>, Hunan University News<\/a><\/em><\/span>,\u00a0Sina News<\/em><\/a>, Sohu News<\/em><\/a>, NSFC News<\/em><\/a>]\"\"<\/a><\/p>\n

\n

Prior Publications<\/h3>\n

[52] \u00a0S.P. Laptenok, J. Conyard, P.C.B. Page, Y. Chan, M. You<\/strong>, S.R. Jaffrey & S.R. Meech. (2016) “Photoacid behavior in a fluorinated green fluorescent protein chromophore: ultrafast formation of anion and zwitterion states”. Chem Sci<\/em><\/a>,\u00a07, 5747-5752.<\/span><\/p>\n

[51] \u00a0Y. Lyu, G. Chen, D. Shangguan, L. Zhang, S. Wan, Y. Wu, H. Zhang, L. Duan, C. Liu, M. You<\/strong>, J. Wang & W. Tan. (2016) “Generating cell targeting aptamers for nanotheranostics using cell-SELEX”. Theranostics<\/em><\/a>, 6, 1440-1452.<\/p>\n

[50] \u00a0J.L. Litke,\u00a0M. You<\/strong>\u00a0& S.R. Jaffrey. (2016) “Developing fluorogenic riboswitches for imaging metabolite concentration dynamics in bacterial cells”. <\/span>Methods Enzymol<\/em><\/a>,\u00a0572, 315-333.<\/em><\/span><\/p>\n

[49] \u00a0D. Han#<\/sup>, C. Wu#<\/sup>, M. You<\/strong>#<\/sup>, T. Zhang, T. Chen, L. Qiu, Z. Zheng & W. Tan. (2015) “A cascade reaction network mimicking the basic functional steps of acquired immune response”. Nature Chemistry<\/a><\/em>, 7, 835-841. (# Co-first author) \"01\"<\/a>
\n<\/a><\/p>\n

[48] \u00a0M. You<\/strong>#<\/sup>, J.L. Litke#<\/sup>\u00a0& S.R. Jaffrey. (2015) “Imaging metabolite dynamics in living cells using a spinach-based riboswitch”. <\/span>Proc Natl Acad Sci USA<\/a><\/em>, 112, E2756-E2765. (# Co-first author) <\/span>[<\/span>Highlighted by Nature Biotechnology<\/em>] \"1\"<\/a><\/p>\n

[47] \u00a0M. You<\/strong> & S.R. Jaffrey. (2015) “Structure and mechanism of RNA mimics of green fluorescent protein”. <\/span>Annu Rev Biophys<\/a><\/em>, 44, 187-206. <\/span><\/p>\n

[46] \u00a0M. You<\/strong>, G. Zhu, M. Altman, J. Wang, T. Chen, M.J. Donovan & W. Tan. (2015) “Programmable and multi parameter DNA-based logic platform for cancer recognition and targeted therapy”. <\/span>J Am Chem Soc<\/a><\/em>, 137, 667-674. [<\/span>ACS editor\u2019s choice;\u00a0Cover story<\/a>]\"0\"<\/p>\n

[45] \u00a0M. You<\/strong> & S.R. Jaffrey. (2015) “Designing optogenetically controlled RNA for regulating biological systems”. <\/span>Ann NY Acad Sci<\/a><\/em>, 1352, 13-19.<\/span><\/p>\n

[44] \u00a0G. Zhu, S. Cansiz, M. You<\/strong>, L. Qiu, D. Han, L. Zhang & W. Tan. (2015) “Nuclease-resistant synthetic drug-DNA adducts: programmable drug-DNA conjugation for targeted anticancer drug delivery”. NPG Asia Mater<\/a><\/em>, 7, e169.<\/p>\n

[43] \u00a0Y. Yang, M. Goetzfried, K. Hidaka, M. You<\/strong>, W. Tan, H. Sugiyama & M. Endo. (2015) “Direct visualization of walking motions of a photocontrolled nanomachine on the DNA nanostructure”. Nano Lett<\/a><\/em>, 15, 6672-6676.<\/p>\n

[42] \u00a0L. Qiu, T. Chen, I. Ocsoy, E. Yasun, C. Wu, G. Zhu, M. You<\/strong>, R. Yu & W. Tan. (2015) “A targeted, size-photocontrollable, nuclear-uptake nanodrug system for drug-resistant cancer therapy”. Nano Lett<\/a><\/em>, 15, 457-463.
\n<\/a><\/p>\n

[41] \u00a0M. You<\/strong>, L. Peng, N. Shao, L. Zhang, L. Qiu, C. Cui & W. Tan. (2014) “DNA ‘nano-claw’: logic-based autonomous cancer targeting and\u00a0therapy”. J Am Chem Soc<\/a><\/em>, 136, 1256-1259.\"04\"<\/a><\/p>\n

[40] \u00a0L. Peng, M. You<\/strong>, C. Wu, D. Han, I. Ocsoy, T. Chen, Z. Chen & W. Tan. (2014) “Reversible phase transfer of nanoparticles based on photoswitchable host-guest chemistry”. ACS Nano<\/a><\/em>, 8, 2555-2561.<\/p>\n

[39] \u00a0F. Huang, M. You<\/strong>, T. Chen, G. Zhu, H. Liang & W. Tan. (2014) “Self-assembled hybrid nanoparticles for targeted co-delivery of two drugs into cancer cells”. Chem Comm<\/a><\/em>, 50, 3103-3105.<\/p>\n

[38] \u00a0L. Qiu, T. Zhang, J. Jiang, C. Wu, G. Zhu, M. You<\/strong>, X. Gao, L. Zhang, R. Yu & W. Tan. (2014) “Cell membrane-anchored biosensors for real-time monitoring of cellular microenvironment”. J Am Chem Soc<\/a><\/em>, 136, 13090-13093.<\/p>\n

[37] \u00a0D. Han, H. Kang, T. Zhang, C. Wu, C. Zhou, M. You<\/strong>, Z. Chen, X. Zhang & W. Tan. (2014) “Nucleic acid based logical systems”. Chem Eur J<\/a><\/em>, 20, 5866-5873.<\/p>\n

[36] \u00a0Y. Liu, T. Chen, C. Wu, L. Qiu, R. Hu, J. Li, S. Cansiz, L. Zhang, G. Zhu, M. You<\/strong>, T. Zhang & W. Tan. (2014) “Facile surface functionalization\u00a0of hydrophobic magnetic nanoparticles”. J Am Chem Soc<\/a><\/em>, 136, 12552-12555.<\/p>\n

[35] \u00a0M. You<\/strong>. (2013) “Molecular beacons for detection of single nucleotide polymorphisms”. In: Molecular Beacons<\/a><\/em>. Springer, Heidelberg, 61-74. (Book chapter)<\/p>\n

[34] \u00a0M. You<\/strong>. (2013) “Engineering molecular beacons for advanced applications”. In: Molecular Beacons<\/a><\/em>. Springer, Heidelberg, 107-122. (Book chapter)<\/p>\n

[33] \u00a0C. Wu, D. Han, T. Chen, L, Peng, G. Zhu, M. You<\/strong>, L. Qiu, K. Sefah & W. Tan. (2013) “Building a multifunctional aptamer-based DNA nanoassembly for targeted cancer therapy”. J Am Chem Soc<\/a><\/em>, 135, 18644-18650. [Highlighted by news (2014) Science-Business eXchange<\/a><\/em>, 2]<\/p>\n

[32] \u00a0L. Qiu, C. Wu, M. You<\/strong>, D. Han, T. Chen, G. Zhu, J. Jiang, R. Yu & W. Tan. (2013) “A targeted, self-delivered and photocontrolled molecular beacon for mRNA detection in living cells”. J Am Chem Soc<\/a><\/em>, 135, 12952-12955.<\/p>\n

[31] \u00a0F. Huang, M. You<\/strong>, D. Han, H. Liang & W. Tan. (2013) “DNA branch migration reactions through photo-controllable toehold formation”. J Am Chem Soc<\/em><\/a>, 135, 7967-7973.<\/p>\n

[30] \u00a0J. Wang, M. You<\/strong>, G. Zhu, M.I. Shukoor, Z. Chen, Z. Zhao, M.B. Altman, Q. Yuan, Z. Zhu, Y. Chen, C. Huang & W. Tan. (2013) “Photosensitizer-gold nanorods composite for targeted multimodal therapy”. Small<\/a><\/em>, 9, 3678-3684.<\/p>\n

[29] \u00a0L. Peng, C. Wu, M. You<\/strong>, D. Han, Y. Chen, T. Fu, M. Ye & W. Tan. (2013) “Engineering and applications of DNA-grafting polymer materials”. Chem Sci<\/a><\/em>, 4, 1928-1938.<\/p>\n

[28] \u00a0J. Zheng, G. Zhu, Y. Li, C. Li, M. You<\/strong>, T. Chen, E. Song, R. Yang & W. Tan. (2013) “A spherical nucleic acid\u00a0platform based on self-assembled DNA biopolymer for cancer therapy”. ACS Nano<\/a><\/em>, 7, 6545-6554.<\/p>\n

[27] \u00a0C. Wu, T. Chen, D. Han, M. You<\/strong>, L. Peng, S. Cansiz, G. Zhu, C. Li, X. Xiong, C.J. Yang & W. Tan. (2013) “Engineering of switchable aptamer micelle flares for molecular imaging in living cells”. ACS Nano<\/a><\/em>, 7, 5724-5731.<\/p>\n

[26] \u00a0Z. Zhao, H. Meng, N. Wang, M.J. Donovan, T. Fu, M. You<\/strong>, X. Zhang & W. Tan. (2013) “A nanocarrier with extracellular pH value driven tumor targeting for drug delivery”. Angew Chem Int Ed<\/a><\/em>, 52, 7487-7491.<\/p>\n

[25] \u00a0T. Chen, C.S. Wu, E. Jimenez, Z. Zhu, J.G. Dajac, M. You<\/strong>, D. Han, X. Zhang & W. Tan. (2013) “DNA micelle flares for intracellular mRNA imaging and gene therapy”. Angew Chem Int Ed<\/a><\/em>, 52, 2012-2016.<\/p>\n

[24] \u00a0I. Ocsoy, M. Paret, M. Ocsoy, S. Kunwar, T. Chen, M. You<\/strong> & W. Tan. (2013) “DNA-directed silver nanoparticles on graphene oxide as an antibacterial against xanthomonas perforans”. ACS Nano<\/a><\/em>, 7, 8972-8980.<\/p>\n

[23] \u00a0C. Li, T. Chen, I. Ocsoy, G. Zhu, E. Yasun, M. You<\/strong>, C. Wu, C. Huang & W. Tan. (2013) “Gold-coated Fe3<\/sub>O4<\/sub> nano roses with five unique functions for cancer cell targeting, imaging and therapy”. Adv Funct Mater<\/a><\/em>, 24, 1772-1780.<\/p>\n

[22] \u00a0J. Wang, K. Sefah, M.B. Altman, T. Chen, M. You<\/strong>, Z. Zhao, C. Huang & W. Tan. (2013) “Aptamer-conjugated nanorods for targeted photothermal therapy of prostate cancer stem cells”. Chem Asian J<\/a><\/em>, 8, 2417-2422.<\/p>\n

[21] \u00a0M. You<\/strong>, Y. Chen, X. Zhang, H. Liu, R. Wang, K.R. Williams & W. Tan. (2012) “An autonomous and controllable light-driven DNA walking device”. Angew Chem Int Ed<\/a><\/em>, 51, 2457-2460. [Inside back cover<\/a>;\u00a0Highlighted by news (2012) DNA walker strides towards the light. Chemistry World<\/a><\/em> of Royal Chemical Society]\"2\"<\/a><\/p>\n

[20] \u00a0M. You<\/strong>, F. Huang, Z. Chen, R. Wang & W. Tan. (2012) “Building a nanostructure with reversible motions using photonic energy”. ACS Nano<\/a><\/em>, 6, 7935-7941. [Highlighted by perspective (2012) Racing with nature: artificial nanomachines that keep running on light, both left and right. ACS Nano<\/a><\/em> 6, 7553-7555;\u00a0Highlighted by news (2012) Photoisomerization drives nanowalker. C & EN<\/a><\/em>, 32, 36]\"02\"<\/a><\/p>\n

[19] \u00a0L. Peng, M. You<\/strong>, Q. Yuan, C. Wu, D. Han, Y. Chen, Z. Zhong, J. Xue & W. Tan. (2012) “Macroscopic volume change of dynamic hydrogels induced by reversible DNA hybridization”. J Am Chem Soc<\/a><\/em>, 134, 12302-12307.<\/p>\n

[18] \u00a0T. Chen, I. Ocsoy, Q. Yuan, M. You<\/strong>, Z. Zhao, E. Song & W. Tan. (2012) “One-step facile surface engineering of hydrophobic nano-crystals with designer molecular recognition”. J Am Chem Soc<\/a><\/em>, 134, 13164-13167.<\/p>\n

[17] \u00a0B. Yin, M. You<\/strong>, W. Tan & B. Ye. (2012) “Mercury (II) ions detection via pyrene-mediated photolysis of disulfide bonds”. Chem Eur J<\/a><\/em>, 18, 1286-1289.<\/p>\n

[16] \u00a0J. Wang, G. Zhu, M. You<\/strong>, E. Song, I. Shukoor, M.B. O\u2019Donoghue, C. Huang & W. Tan. (2012) “Assembly of aptamer switch probes and photosensitizer on gold nanorods for targeted photothermal and cancer therapy”. ACS Nano<\/a><\/em>, 6, 5070-5077.<\/p>\n

[15] \u00a0C. Wu, L. Peng, M. You<\/strong>, D. Han, T. Chen, K.R. Williams, C.J. Yang & W. Tan. (2012) “Engineering molecular beacons for intracellular imaging”. Int J Mol Imaging<\/a><\/em>, 501579.<\/p>\n

[14] \u00a0X. Tan, W. Chen, S. Lu, Z. Zhu, T. Chen, G. Zhu, M. You<\/strong> & W. Tan. (2012) “Molecular beacon aptamers for direct and universal quantitation of recombinant proteins from cell lysates”. Anal Chem<\/a><\/em>, 84, 8272-8276.<\/p>\n

[13] \u00a0M. You<\/strong>, R. Wang, X. Zhang, Y. Chen, K. Wang & W. Tan. (2011) “Photon-regulated DNA-enzymatic nanostructures by molecular assembly”. ACS Nano<\/a><\/em>, 5, 10090-10095.<\/p>\n

[12] \u00a0M. You<\/strong>, Y. Chen, L. Peng, D. Han, B. Yin, B. Ye & W. Tan. (2011) “Engineering DNA aptamers for novel analytical and biomedical applications”. Chem Sci<\/a><\/em>, 2, 1003-1010.<\/p>\n

[11] \u00a0<\/strong>J. Liu#<\/sup>, M. You<\/strong>#<\/sup>, Y. Pu, H. Liu, Y. Mao & W. Tan. (2011) “Recent developments in protein and cell-targeted aptamer selection and applications”. Curr Med Chem<\/a><\/em>, 18, 4117-4125. (# Co-first author)<\/p>\n

[10] \u00a0M. You<\/strong>, Y. Wang, H. Wang & R. Yang. (2011) “Fluorescent detection of singlet oxygen: amplifying signal transduction based on intramolecular FRET of anthryl appended porphyrins”. Chinese Sci Bull<\/a><\/em>, 56, 3253-3259.<\/p>\n

[9] \u00a0K. Wang, M. You<\/strong>, Y. Chen, D. Han, Z. Zhu, J. Huang, K.R. Williams & W. Tan. (2011) “Self-assembly of a bifunctional DNA carrier for drug delivery”. Angew Chem Int Ed<\/a><\/em>, 50, 6098-6101.<\/p>\n

[8] \u00a0D. Han, J. Huang, Z. Zhu, Q. Yuan, M. You<\/strong>, Y. Chen & W. Tan. (2011) “Molecular engineering of photoresponsive three-dimensional DNA nanostructures”. Chem Comm<\/a><\/em>, 47, 4670-4672.<\/p>\n

[7] \u00a0D. Lopez-Colon, E. Jimenez, M. You<\/strong> & B. Gulbakan. (2011) “Aptamers: turning the spotlight on cells”. WIREs Nanomed Nanobio<\/a><\/em>, 3, 328-340.<\/p>\n

[6] \u00a0J.A. Phillips, H. Liu, M.B. O\u2019Donoghue, X. Xiong, M. You<\/strong>, K. Sefah & W. Tan. (2011) “Using azobenzene incorporated DNA aptamers to probe molecular binding interactions”. Bioconjugate Chem<\/a><\/em>, 22, 282-288.<\/p>\n

[5] \u00a0M. You<\/strong>, Z. Zhu,<\/strong> H. Liu, B. Gulbakan, D. Han, R. Wang, K.R. Williams & W. Tan. (2010) “Pyrene-assisted efficient photolysis of disulfide bonds in DNA-based molecular engineering”. ACS Appl Mater Interfaces<\/a><\/em>, 2, 3601-3605.
\n<\/a><\/p>\n

[4] \u00a0Z. Zhu, R. Yang, M. You<\/strong>, X. Zhang, Y. Wu & W. Tan. (2010) “Single-walled carbon nanotube as an effective quencher”. Anal Bioanal Chem<\/a><\/em>, 396, 73-83.<\/p>\n

[3] \u00a0B. Gulbakan, E. Yasun, M.I. Shukoor, Z. Zhu, M. You<\/strong>, X. Tan, H. Sanchez, D.H. Powell, H. Dai & W. Tan. (2010) “A dual platform for selective analyte enrichment and ionization in mass spectrometry using aptamer-conjugated graphene oxide”. J Am Chem Soc<\/a><\/em>, 132, 17408-17410. [Highlighted by news (2010) Aptamer-graphene combos pull analytic double duty. C & EN<\/a><\/em>, 49, 36]<\/p>\n

[2] \u00a0J. Huang, Z. Zhu, S. Bamrungsap, G. Zhu, M. You<\/strong>, X. He, K. Wang & W. Tan. (2010) “Competition-mediated pyrene-switching aptasensor: probing lysozyme in human serum with a monomer-excimer fluorescence switch”. Anal Chem<\/a><\/em>, 82, 10158-10163.<\/p>\n

[1] \u00a0L. Long, M.<\/strong> You<\/strong>, H. Wang, Y. Wang & R. Yang. (2009) “A fluorescent sensing membrane for iodine based on intramolecular excitation energy transfer of anthryl appended porphyrin”. Sci China Ser B<\/a><\/em>, 39, 532-540.<\/p>\n","protected":false},"excerpt":{"rendered":"

Publications at\u00a0UMass (* Corresponding author;\u00a0 # Co-first author;\u00a0 \u00a0^ Undergraduate author) 2026 [106]\u00a0 A. Hecht#, Q. Yu#, & M. You*. (2026) “Rational development of fluorogenic RNA sensors for live-cell imaging”. \u00a0RNA Scaffolds: Methods and Protocols, 3rd Edition, submitted.\u00a0 [Invited book …<\/p>\n

Publications<\/span> Read More »<\/a><\/p>\n","protected":false},"author":50,"featured_media":0,"parent":0,"menu_order":4,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-14","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/elements.chem.umass.edu\/youlab\/wp-json\/wp\/v2\/pages\/14","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/elements.chem.umass.edu\/youlab\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/elements.chem.umass.edu\/youlab\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/elements.chem.umass.edu\/youlab\/wp-json\/wp\/v2\/users\/50"}],"replies":[{"embeddable":true,"href":"https:\/\/elements.chem.umass.edu\/youlab\/wp-json\/wp\/v2\/comments?post=14"}],"version-history":[{"count":479,"href":"https:\/\/elements.chem.umass.edu\/youlab\/wp-json\/wp\/v2\/pages\/14\/revisions"}],"predecessor-version":[{"id":2470,"href":"https:\/\/elements.chem.umass.edu\/youlab\/wp-json\/wp\/v2\/pages\/14\/revisions\/2470"}],"wp:attachment":[{"href":"https:\/\/elements.chem.umass.edu\/youlab\/wp-json\/wp\/v2\/media?parent=14"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}