{"id":1886,"date":"2022-03-09T23:15:23","date_gmt":"2022-03-10T03:15:23","guid":{"rendered":"https:\/\/elements.chem.umass.edu\/youlab\/?page_id=1886"},"modified":"2026-04-15T12:20:48","modified_gmt":"2026-04-15T16:20:48","slug":"representative-publications","status":"publish","type":"page","link":"https:\/\/elements.chem.umass.edu\/youlab\/publications\/representative-publications\/","title":{"rendered":"Representative"},"content":{"rendered":"

<\/h3>\n

Publications at UMass<\/h3>\n

[22]<\/strong>\u00a0 M. M. R. Singuru*, P. Bhattacharyya, & M. You*. (2026) “Mechanically triggered DNA Nanovehicles for targeted dual-drug cancer therapy”.\u00a0 Adv Sci<\/em><\/a>, <\/span>in press.<\/p>\n

[21]<\/strong>\u00a0 M. M. R. Singuru*, P. Bhattacharyya, H. P. Sriramakrishnan, & M. You*. (2025) “Sensitive detection of intercellular tensile forces via Cas12a-assisted membrane molecular probes”.\u00a0 Nano Letters<\/em><\/a>, <\/span>25, 13519\u201313525.<\/p>\n

[20]<\/strong>\u00a0 M. M. R. Singuru,* M. A. Tabrizi, P. Bhattacharyya, A. A. Ali, & M. You*. (2025) “Force-responsive delivery of anticancer drugs via a DNA mechanical nanovehicle”. \u00a0Nano Letters<\/em><\/a><\/span>, 25<\/span>, <\/span>336-342.<\/span><\/p>\n

[19]<\/strong>\u00a0 R. Zheng#, R. Wu#*, Y. Liu, Z. Sun, Z. Xue, Y. Bagheri, S. Khajouei, L. Mi, Q. Tian, R. Pho^, Q. Liu^, S. Siddiqui^, K. Ren*, & M. You*. (2024) “Multiplexed sequential imaging in living cells with orthogonal fluorogenic RNA aptamer\/dye pairs”. \u00a0Nucleic Acids Research<\/em><\/a>, 52, e67.<\/p>\n

[18]<\/strong>\u00a0 M. A. Tabrizi,* P. Bhattacharyya, R. Zheng, & M. You*. (2024) “Electrochemical DNA-based sensors for measuring cell-generated forces”. Biosens Bioelectron<\/em><\/a>, 253, 116185<\/p>\n

[17]<\/strong>\u00a0 Z. Xue#, K. Ren#*, R. Wu, Z. Sun, R. Zheng, Q. Tian, A. A. Ali, L. Mi, & M. You*. (2023) “Targeted RNA condensation in living cells via genetically encoded triplet repeat tags”. Nucleic Acids Res<\/em><\/a><\/span>, 51, 8337-8347.<\/p>\n

[16]\u00a0<\/strong> L. Mi#, Q. Yu#, A.P.K.K. Karunanayake Mudiyanselage, R. Wu, Z. Sun, R. Zheng, K. Ren*, & M. You*. (2023) “Genetically encoded RNA-based bioluminescence resonance energy transfer (BRET) sensors”.\u00a0\u00a0 ACS Sensors<\/em><\/a>, 8, 308-316.<\/p>\n

[15]\u00a0<\/strong> A. A. Ali, Y. Bagheri*, Q. Tian, & M. You*. (2022) “Advanced DNA Zipper probes for detecting cell membrane lipid domains”. \u00a0Nano Letters<\/em><\/a>, 22, 7579-7587.<\/p>\n

[14]\u00a0<\/strong> Y. Bagheri#, A. A. Ali#, P. Keshri, J. Chambers, A. Gershenson*, & M. You*. (2022) “Imaging membrane order and dynamic interactions in living cells with a DNA Zipper probe”. \u00a0Angew Chem Int Ed<\/a><\/em>, 61, e202112033.<\/p>\n

[13]\u00a0<\/strong> Z. Sun, R. Wu, B. Zhao, P. Chien*, & M. You*. (2021) “Live-cell imaging of guanosine tetra- and pentaphosphate (p)ppGpp with RNA-based fluorescent sensors”.\u00a0 Angew Chem Int Ed<\/a><\/em>, 60, 24040-24047.<\/p>\n

[12]\u00a0<\/strong> P. Keshri#, B. Zhao#*, T. Xie, Y. Bagheri, J. Chambers, Y. Sun, & M. You*. (2021) “Quantitative and multiplexed fluorescence lifetime imaging of intercellular tensile forces”.\u00a0 Angew Chem Int Ed<\/a><\/em>, 60, 15548-15555.\u00a0 [recognized as a Very Important Paper<\/em>]<\/p>\n

[11]\u00a0<\/strong> Q. Tian, Y. Bagheri, P. Keshri, R. Wu, K. Ren, Q. Yu, B. Zhao, & M. You*. (2021) “Efficient and selective DNA modification on bacterial membranes”. \u00a0Chem Sci<\/em><\/a>, 12, 2629-2634.<\/p>\n

[10]\u00a0<\/strong> K. Ren, P. Keshri, R. Wu, Z. Sun, Q. Yu, Q. Tian, B. Zhao, Y. Bagheri, Y. Xie^, & M. You*. (2020) “A genetically encoded RNA photosensitizer for targeted cell regulation”.\u00a0 Angew Chem Int Ed<\/a><\/em>, 59, 218986-21990.<\/p>\n

[9]\u00a0<\/strong> \u00a0B. Zhao, N. Li, T. Xie, Y. Bagheri, C. Liang, P. Keshri, Y. Sun*, & M. You*. (2020) “Quantifying tensile forces at cell-cell junctions with a DNA-based fluorescent probe”.\u00a0 Chem Sci<\/em><\/a>, 11, 8558-8566.<\/p>\n

[8]\u00a0<\/strong> \u00a0K. Ren, R. Wu, A.P.K.K. Karunanayake Mudiyanselage, Q. Yu, B. Zhao, Y. Xie^, Y. Bagheri, Q. Tian, & M. You*. (2020) “In situ genetically cascaded amplification for imaging RNA subcellular locations”.\u00a0 J Am Chem Soc<\/em><\/a>, 142, 2968-2974.<\/i><\/p>\n

[7]\u00a0<\/strong> \u00a0Y. Bagheri, S. Chedid^, F. Shafiei, B. Zhao*, & M. You*. (2019) “Quantitative assessment of the dynamic modification of lipid-DNA probes on live cell membranes”.\u00a0 Chem Sci<\/em><\/a>, 10, 11030-11040.\u00a0 \u00a0[2019 Chemical Science HOT Article]<\/p>\n

[6]\u00a0<\/strong> \u00a0R. Wu, A.P.K.K. Karunanayake Mudiyanselage, F. Shafiei, B. Zhao, Y. Bagheri, Q. Yu, K. McAuliffe^, K. Ren, & M. You*. (2019) “Genetically encoded ratiometric RNA-based sensors for quantitative imaging of small molecules in living cells”. \u00a0Angew Chem Int Ed<\/a><\/em>, 58, 18271-18275.<\/p>\n

[5]\u00a0<\/strong> \u00a0M. You*, J.L. Litke,\u00a0<\/span>R. Wu, & S.R. Jaffrey*. (2019) “Detection of low-abundance metabolites in live cells using an RNA integrator”. \u00a0Cell Chem Biol<\/a>, <\/em>26, 471-481.\u00a0 \u00a0[See also Cell Chem Biol Preview<\/a><\/em><\/span>]<\/p>\n

[4]\u00a0<\/strong> \u00a0Q. Yu#, J. Shi#, A.P.K.K. Karunanayake Mudiyanselage, R. Wu, B. Zhao, M. Zhou* & M. You*. (2019) “Genetically encoded RNA sensors for intracellular imaging of silver ions”.\u00a0 Chem Commun<\/a>, <\/em>55, 707-710.<\/p>\n

[3]\u00a0<\/strong> \u00a0A.P.K.K. Karunanayake Mudiyanselage, Q. Yu, M.A. Leon-Duque^, B. Zhao, R. Wu & M. You*. (2018) “Genetically encoded catalytic hairpin assembly for sensitive RNA imaging in live cells”.\u00a0 J Am Chem Soc<\/em><\/a>, 140, 8739-8745.<\/p>\n

[2]\u00a0<\/strong> \u00a0B. Zhao, C. O\u2019Brien^, A.P.K.K. Karunanayake Mudiyanselage, N. Li, Y. Bagheri, R. Wu, Y. Sun & M. You*. (2017) “Visualizing intercellular tensile forces by DNA-based membrane molecular probes”.\u00a0 J Am Chem Soc<\/em><\/a>, 139, 18182-18185.<\/p>\n

[1]\u00a0<\/span> <\/strong>\u00a0<\/span>M. You#*<\/strong>, Y. Lyu#, D. Han#, L. Qiu, Q. Liu, T. Chen, C. Wu, L. Peng, L. Zhang, G. Bao & W. Tan*. (2017) “DNA probes for monitoring dynamic and transient molecular encounters on live cell membranes”. \u00a0Nature Nanotechnology<\/em><\/a>, 12, 453-459.\u00a0 \u00a0[See also Nat Nano\u00a0News and Views<\/a><\/em>, Hunan University News<\/a><\/em><\/span>,\u00a0Sina News<\/em><\/a>, Sohu News<\/em><\/a>, NSFC News<\/em><\/a>]<\/p>\n

\n

Prior Publications<\/h3>\n

[12]\u00a0 <\/strong>D. Han#, C. Wu#, M. You#, T. Zhang, T. Chen, L. Qiu, Z. Zheng & W. Tan. (2015) “A cascade reaction network mimicking the basic functional steps of acquired immune response”. Nature Chemistry<\/a><\/em>, 7, 835-841. (# Co-first author)<\/p>\n

[11]\u00a0 <\/strong><\/strong>M. You#, J.L. Litke# & S.R. Jaffrey. (2015) “Imaging metabolite dynamics in living cells using a spinach-based riboswitch”. <\/span>Proc Natl Acad Sci USA<\/a><\/em>, 112, E2756-E2765. (# Co-first author) <\/span>[<\/span>Highlighted by Nature Biotechnology<\/em>]<\/p>\n

[10]\u00a0 <\/strong><\/strong>M. You, G. Zhu, M. Altman, J. Wang, T. Chen, M.J. Donovan & W. Tan. (2015) “Programmable and multi parameter DNA-based logic platform for cancer recognition and targeted therapy”. <\/span>J Am Chem Soc<\/a><\/em>, 137, 667-674. [<\/span>ACS editor\u2019s choice;\u00a0Cover story<\/a>]<\/p>\n

[9]\u00a0\u00a0 <\/strong>L. Peng, M. You, C. Wu, D. Han, I. Ocsoy, T. Chen, Z. Chen & W. Tan. (2014) “Reversible phase transfer of nanoparticles based on photoswitchable host-guest chemistry”. ACS Nano<\/a><\/em>, 8, 2555-2561.<\/p>\n

[8]\u00a0\u00a0 <\/strong>M. You, L. Peng, N. Shao, L. Zhang, L. Qiu, C. Cui & W. Tan. (2014) “DNA ‘nano-claw’: logic-based autonomous cancer targeting and\u00a0therapy”. J Am Chem Soc<\/a><\/em>, 136, 1256-1259.<\/p>\n

[7]\u00a0\u00a0 <\/strong>F. Huang, M. You, D. Han, H. Liang & W. Tan. (2013) “DNA branch migration reactions through photo-controllable toehold formation”. J Am Chem Soc<\/em><\/a>, 135, 7967-7973.<\/p>\n

[6]\u00a0\u00a0 <\/strong>M. You, Y. Chen, X. Zhang, H. Liu, R. Wang, K.R. Williams & W. Tan. (2012) “An autonomous and controllable light-driven DNA walking device”. Angew Chem Int Ed<\/a><\/em>, 51, 2457-2460. [Inside back cover<\/a>;\u00a0Highlighted by news (2012) DNA walker strides towards the light. Chemistry World<\/a><\/em> of Royal Chemical Society]<\/p>\n

[5]\u00a0\u00a0 <\/strong>M. You, F. Huang, Z. Chen, R. Wang & W. Tan. (2012) “Building a nanostructure with reversible motions using photonic energy”. ACS Nano<\/a><\/em>, 6, 7935-7941. [Highlighted by perspective (2012) Racing with nature: artificial nanomachines that keep running on light, both left and right. ACS Nano<\/a><\/em> 6, 7553-7555;\u00a0Highlighted by news (2012) Photoisomerization drives nanowalker. C & EN<\/a><\/em>, 32, 36]<\/p>\n

[4]\u00a0\u00a0 <\/strong>L. Peng, M. You, Q. Yuan, C. Wu, D. Han, Y. Chen, Z. Zhong, J. Xue & W. Tan. (2012) “Macroscopic volume change of dynamic hydrogels induced by reversible DNA hybridization”. J Am Chem Soc<\/a><\/em>, 134, 12302-12307.<\/p>\n

[3]\u00a0\u00a0 <\/strong>M. You, R. Wang, X. Zhang, Y. Chen, K. Wang & W. Tan. (2011) “Photon-regulated DNA-enzymatic nanostructures by molecular assembly”. ACS Nano<\/a><\/em>, 5, 10090-10095.<\/p>\n

[2] <\/strong>\u00a0 K. Wang, M. You, Y. Chen, D. Han, Z. Zhu, J. Huang, K.R. Williams & W. Tan. (2011) “Self-assembly of a bifunctional DNA carrier for drug delivery”. Angew Chem Int Ed<\/a><\/em>, 50, 6098-6101.<\/p>\n

[1]\u00a0\u00a0 <\/strong>M. You, Z. Zhu,<\/strong> H. Liu, B. Gulbakan, D. Han, R. Wang, K.R. Williams & W. Tan. (2010) “Pyrene-assisted efficient photolysis of disulfide bonds in DNA-based molecular engineering”. ACS Appl Mater Interfaces<\/a><\/em>, 2, 3601-3605.<\/p>\n","protected":false},"excerpt":{"rendered":"

Publications at UMass [22]\u00a0 M. M. R. Singuru*, P. Bhattacharyya, & M. You*. (2026) “Mechanically triggered DNA Nanovehicles for targeted dual-drug cancer therapy”.\u00a0 Adv Sci, in press. [21]\u00a0 M. M. R. Singuru*, P. Bhattacharyya, H. P. Sriramakrishnan, & M. You*. …<\/p>\n

Representative<\/span> Read More »<\/a><\/p>\n","protected":false},"author":50,"featured_media":0,"parent":14,"menu_order":1,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-1886","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/elements.chem.umass.edu\/youlab\/wp-json\/wp\/v2\/pages\/1886","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/elements.chem.umass.edu\/youlab\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/elements.chem.umass.edu\/youlab\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/elements.chem.umass.edu\/youlab\/wp-json\/wp\/v2\/users\/50"}],"replies":[{"embeddable":true,"href":"https:\/\/elements.chem.umass.edu\/youlab\/wp-json\/wp\/v2\/comments?post=1886"}],"version-history":[{"count":37,"href":"https:\/\/elements.chem.umass.edu\/youlab\/wp-json\/wp\/v2\/pages\/1886\/revisions"}],"predecessor-version":[{"id":2455,"href":"https:\/\/elements.chem.umass.edu\/youlab\/wp-json\/wp\/v2\/pages\/1886\/revisions\/2455"}],"up":[{"embeddable":true,"href":"https:\/\/elements.chem.umass.edu\/youlab\/wp-json\/wp\/v2\/pages\/14"}],"wp:attachment":[{"href":"https:\/\/elements.chem.umass.edu\/youlab\/wp-json\/wp\/v2\/media?parent=1886"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}