Most Recent Publications (published in the past twelve months):
S.N. Nguyen, S.H. Le, D.G. Ivanov, N. Ivetic, I. Nazy, I.A. KaltashovA. Structural characterization of a pathogenic antibody underlying vaccine-induced immune thrombotic thrombocytopenia (VITT). Anal. Chem., 2024, in press (doi: 10.1021/acs.analchem.3c05253)
Yang, Y. Du, D.G. Ivanov, C. Niu, R. Clare, J.E. Smith, I. Nazy and I.A. Kaltashov. Molecular architecture and platelet-activating properties of small immune complexes assembled on heparin and platelet factor 4. Comm. Biol. 2024, 7, 308 (doi: 10.1038/s42003-024-05982-4)
Y. Yang, D.G. Ivanov, M.D. Levin, B. Olenyuk, O. Cordova-Robles, B. Cederstrom, J.E. Schnitzer, and I.A. Kaltashov. Characterization of large immune complexes with size exclusion chromatography and native mass spectrometry supplemented with gas phase ion chemistry. Anal. Chem., 2024, 96, 2822-2829 (doi: 10.1021/acs.analchem.3c03278)
I.A. Kaltashov, D.G. Ivanov and Y. Yang. Mass spectrometry-based methods to characterize highly heterogeneous biopharmaceuticals, vaccines and nonbiological complex drugs at the intact-mass level. Mass Spectrom. Rev. 2024, 43, 139-165 (doi: 10.1002/mas.21829)
D. G. Ivanov, N. Ivetic, Y. Du, S.N. Nguyen, S.H. Le, D. Favre, I. Nazy, I.A. Kaltashov. Reverse Engineering of a Pathogenic Antibody Reveals the Molecular Mechanism of Vaccine-Induced Immune Thrombotic Thrombocytopenia. J. Am. Chem. Soc. 2023, 145, 25203-25213 (doi: 10.1021/jacs.3c07846)
Representative Publications from Prior Years (limited to one per year):
- W. Yang, D.G. Ivanov and I.A. Kaltashov. Extending the capabilities of intact-mass analyses to monoclonal immunoglobulins of the E-isotype (IgE). MAbs 2022, 14, 2103906 (doi: 10.1080/19420862.2022.2103906)
- Y. Yang, C. Niu. C.E. Bobst and I.A. Kaltashov. Charge manipulation using solution and gas-phase chemistry to facilitate analysis of highly heterogeneous protein complexes in native mass spectrometry. Anal. Chem. 2021, 93, 3337-3342
- Y. Yang, Y. Du and I.A. Kaltashov. The utility of native MS for understanding the mechanism of action of repurposed therapeutics in COVID-19: heparin as a disruptor of the SARS-CoV-2 interaction with its host cell receptor. Anal. Chem. 2020, 92, 10930-10934
- C. Ren, C.E. Bobst and I.A. Kaltashov. Exploiting His-Tags for Absolute Quantitation of Exogenous Recombinant Proteins in Biological Matrices: Ruthenium as a Protein Tracer. Anal. Chem., 2019, 91, 7189
- Pawlowski, J., et.al. Integration of On-Column Chemical Reactions in Protein Characterization by Liquid Chromatography/Mass Spectrometry: Cross-Path Reactive Chromatography. Anal. Chem. 2018, 90, 1348
- K. Muneeruddin, et al. Characterization of a PEGylated protein therapeutic by ion exchange chromatography with on-line detection by native ESI MS and MS/MS. Analyst 2017, 142, 336
- Y. Zhao, et al. Interactions of intact unfractionated heparin with its client proteins can be probed directly using native electrospray ionization mass spectrometry. Anal. Chem. 2016, 88, 1711
- K. Muneeruddin, et al. Characterization of intact protein conjugates and biopharmaceuticals using ion-exchange chromatography with online detection by native electrospray ionization mass spectrometry and top-down tandem mass spectrometry. Anal. Chem. 2015, 87, 10138
- K. Muneeruddin, et al. Characterization of small protein aggregates and oligomers using size exclusion chromatography with on-line detection by native electrospray ionization mass spectrometry. Anal. Chem. 2014, 86, 10692
- G. Wang, et al. Conformer-specific characterization of non-native protein states with high spatial resolution using hydrogen exchange and top-down mass spectrometry. Proc. Natl. Acad. Sci. U.S.A. 2013, 110, 20087
- C.E. Bobst, et al. Mass spectrometry study of a transferrin-based protein drug reveals the key role of protein aggregation for successful oral delivery. Proc. Natl. Acad. Sci. U.S.A. 2012, 109, 13544