Nucleic acids for RNA interference and other therapeutic applications represent a new mode of treating disease. However, due to their inherent characteristics, their potential remains untapped. Alongside the Rotello research group (Department of Chemistry, UMass Amherst), we are working to develop agents for delivery of nucleic acids and small drug-like molecules as cancer therapeutics. Nanoparticle stabilized capsules are entities held together by non-covalent interactions, consisting of gold nanoparticles, nucleic acids, and lipophilic fatty acids, which possess a unique mechanism for cellular uptake that circumvents entrapment in cellular compartments. We are targeting NPSCs toward cancer relevant markers and utilizing them to co-deliver established therapeutics, exploring their use in models of disease.