Target Protein Degradation

308)

Singh, B.; Das, P.; Majee, A.; Tajdi, A.; Devarajan, A.; Lomeli, A.; Talluri, A.; Dutta, R* & Thayumanavan, S.*. “Enzyme Activation of Triggerable Polymeric Lysosome Targeting Chimeras.” bioRxiv 2026.

307)

Dutta, R*; Alp, Y*; Gupta, P*; Singh, B*; Thayumanavan, S. ” Expanding the Repertoire of Lysosomal Degradation of Membrane Proteins: A Generalizable Strategy Using Multivalent Antibody−Polymer Chimeras” J. Am. Chem. Soc. 2026

304)

Lu, R. H. H.*, Krishna, J.*, Alp, Y., & Thayumanavan, S. Polymeric Lysosome-Targeting Chimeras (PolyTACs): Extracellular Targeted Protein Degradation without Co-Opting Lysosome-Targeting Receptors. J. Am. Chem. Soc. 2026, 148(1), 1259-1270.

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Dutta, R.*; Alp, Y.*; Gupta, P.*; Singh, B.*, & Thayumanavan, S. “Multivalent Ligand-Protein Interactions Using Polymeric Lysosome-Targeting Chimeras (PolyTACs) Leads to Lysosome-Targeting Receptor-Independent Degradation of Transmembrane Proteins.” bioRxiv, 2025-05.

 

295)
Dutta, R. *; Devarajan, A.*; Talluri, A.; Das, R.; and Thayumanavan, S.; “Dual-Action-Only PROTACs” Journal of the American Chemical Society, 2025(10.1021/jacs.5c00131)
Figure 1
292)

Lu, H.H.*; Krishna, J*; Alp, Y; Thayumanavan S.” Polymeric Lysosomal-Targeting Chimeras: Extracellular Targeted Protein Degradation Without Co-opting Lysosome-Targeting Receptors” BioRxiv, (https://doi.org/10.1101/2024.09.18.613672)