Responsive Assemblies and Materials


Raghupathi, K.; Thayumanavan, S. “Nano-Armoring of Enzymes: Rational Design of Polymer-Wrapped Enzymes” Methods Enzymol. 2017, 589, in press. (DOI: 10.1016/bs.mie.2017.01.007)


Zhuang, J.; Garzoni, M.; Torres, D. A.; Poe, A.; Pavan, P. M.; Thayumanavan, S. “Programmable Nanoassemblies from Non-Assembling Homopolymers Using Ad Hoc Electrostatic Interactions” Angew. Chem. Int. Ed. 2017, 56, Early View. (DOI: 10.1002/anie.201611688)


Liu, B.; Thayumanavan, S. “Substituent Effects on the pH Sensitivity of Acetals and Ketals and Their Correlation with Encapsulation Stability in Polymeric Nanogels” J. Am. Soc. Chem. 2017, 139, 2306–2317. (DOI: 10.1021/jacs.6b11181)


Liu, X.; Ding, H.; Jiang, Z.; Zhuang, J.; Xu, Y.; Guo, X.; Thayumanavan, S. “Multi-Stimuli-Responsive Amphiphilic Assemblies through Simple Postpolymerization Modifications” Macromolecules 2016, 49, 6186–6192. (DOI: 10.1021/acs.macromol.6b01397)


Rangadurai, P.; Molla, M. R.; Prasad, P.; Caissy, M.; Thayumanavan, S. “Temporal and Triggered Evolution of Host-Guest Characteristics in Amphiphilic Polymer Assemblies” J. Am. Chem. Soc. 2016, 138, 7508–7511. (DOI: 10.1021/jacs.6b04099)


Wang, H.; Zhuang, J.; Raghupathi, K. R.; Thayumanavan, S. “A Supramolecular Dissociation Strategy for Protein Sensing” Chem. Commun. 2015, 51, 17265–17268. (DOI: 10.1039/C5CC07408H)


Prasad, P.; Molla, M. R.; Cui, W.; Canakci, M.; Osborne, B.; Mager, J.; Thayumanavan, S. “Polyamide Nanogels from GRAS Components and Their Toxicity in Mouse Pre-implantation Embryos” Biomacromolecules 2015, 16, 3491–3498. (DOI: 10.1021/acs.biomac.5b00900)


Ventura, J.; Eron, S. J.; González-Toro, D. C.; Raghpathi, K. R.; Wang, F.; Hardy, J. A.; Thayumanavan, S. “Reactive Self-Assembly of Polymers and Proteins to Reversibly Silence a Killer Protein” Biomacromolecules 2015, 16, 3161–3171. (DOI: 10.1021/acs.biomac.5b00779)


Molla, M. R.; Prasad, P.; Thayumanavan, S. “Protein‐Induced Supramolecular Disassembly of Amphiphilic Polypeptide Nanoassemblies” J. Am. Chem. Soc. 2015, 137, 7286-7289. (DOI: 10.1021/jacs.5b04285) (R,S)170


Song, C.; Li, L.; Dai, L.; Thayumanavan, S. “Responsive Single Chain Polymer Nanoparticles with Host-Guest Features” Polym. Chem. 2015, 6, 4828-4834. (DOI: 10.1039/C5PY00600G) (R)



Raghupathi, K. R.; Sridhar, U.; Byrne, K.; Raghupathi, K. R.; Thayumanavan, S. “Influence of Backbone Conformational Rigidity in Temperature-Sensitive Amphiphilic Supramolecular Assemblies” J. Am. Chem. Soc. 2015, 137, 5308-5311 (DOI: 10.1021/jacs.5b02108). (R, S)168


Wang, Hui; Raghupathi, K.; Zhuang, J.; Thayumanavan, S. “Activatable Dendritic 19F Probes for Enzyme Detection” ACS Macro Letters, 2015, 4, 422-425 (DOI: 10.1021/acsmacrolett.5b00199). (R, S)167


Yuan, C.; Chang, Y.; Mao, J.; Yu, S.; Luo, W.; Xu, Y.; Thayumanavan, S.; Dai, L. “Supramolecular Assembly of Crosslinkable Monomers for Degradable and Fluorescent Polymer Nanoparticles” J. Mater. Chem. B. , 2015, 2858-2866  (DOI: 10.1039/c4tb01880j).  (R,S)





Li, L.; Song, C.; Jennings, M.; Thayumanavan, S. “Photoinduced Heterodisulfide Metathesis for Reagent-free Synthesis of Polymer Nanoparticles” Chem. Commun. 2015, 51, 1425-1428 (DOI: 10.1039/c4cc08000a). (R)



Molla, M. R.; Rangadurai, P.; Pavan, G. M.; Thayumanavan, S. “Experimental and Theoretical Investigations in Stimuli Responsive Dendrimer-based Assemblies” Nanoscale, 2015, 7, 3817-3837 (DOI: 10.1039/C4NR04563G). (R,S)



Molla, M. R.; Marcinko, T.; Prasad, P.; Deming, D.; Garman, S.; Thayumanavan, S. “Unlocking a Caged Lysosomal Protein from a Polymeric Nanogel with a pH Trigger” Biomacromolecules, 2014, 15, 4046-4053 (DOI: 10.1021/bm501091p). (R,S)



Li, L.; Thayumanavan, S. “Environment-Dependent Guest-Exchange in Supramolecular Hosts” Langmuir, 2014, 30, 12384-12390 (DOI: 10.1021/la502760c). (R,S)



Li, L.; Yuan, C.; Dai, L.; Thayumanavan, S. “Thermo-responsive Polymeric Nanoparticles: Nucleation from Cooperative Polymerization Driven by Dative Bonds” Macromolecules, 2014, 47, 5869-5876 (DOI: 10.1021/ma5015808). (R,S)



Raghupathi, K.; Guo, J.; Munkhbat, O.; Rangadurai, P.; Thayumanavan, S. “Supramolecular Assembly and Disassembly of Facially Amphiphilic Dendrimers” Acc. Chem. Res. 201447, 2200-2211 (Invited Review)  (DOI: 10.1021/ar500143u) (PMCID# PMC4100797). (R,S)



Amado Torres, D.; Garzoni, M.; Subrahmanyam, A.; Pavan, G. M.; Thayumanavan, S. “Protein-Triggered Supramolecular Disassembly: Insights Based on Variations in Ligand Location in Amphiphilic Dendrons” J. Am. Chem. Soc. 2014, 136, 5385-5399. (DOI: 10.1021/ja500634u ) (R,S) 155


Guo, J.; Zhuang, J.; Wang, F.; Raghupathi, K.; Thayumanavan, S. “Protein AND Enzyme Gated Supramolecular Disassembly”  J. Am. Chem. Soc. 2014, 136, 2220-2223   (DOI: 10.1021/ja4108676) (R,S). 



Zhuang, J.; Chacko, R.; Amado Torres, D.; Wang, H.; Thayumanavan, S. “Dual Stimuli – Dual Response Nanoassemblies Prepared from a Simple Homopolymer” ACS Macro Lett. 2014, 3, 1-5 (DOI: 10.1021/mz400515s) (R,S).



Raghupathi, K.; Li, L.; Ventura, J.; Jennings, M.; Thayumanavan, S. “pH Responsive Soft Nanoclusters with Size and Charge Conversional Features” Polym. Chem. 2014, 5, 1737-1742. (DOI:10.1039/C3PY01277H) (R,S)



Yuan, C.; Raghupathi, K.; Popere, B. C.; Ventura, J.; Dai, L.; Thayumanavan, S. “Composite Supramolecular Nanoassemblies with Independent Stimulus Sensitivities”  Chem. Sci. 2014, 5, 229-234. (DOI:10.1039/C3SC52347K) (R,S)




Wang, H.; Zhuang, J.; Thayumanavan, S. ““Functionalizable Amine-based Polymer Nanoparticles” ACS Macro Lett. 2013, 2, 948-951. (DOI: 10.1021/mz4004248) (R,S)



Li, L.; Raghupathi, K.; Yuan, C.; Thayumanavan, S. “Surface Charge Generation in Nanogels for Activated Cellular Uptake at Tumor-Relevant pH” Chem. Sci. 2013, 4, 3654-3660. (DOI: 10.1039/C3SC50899D) (R,S)144



Fuller, J.; Raghupathi, K.; Ramireddy, R. R.; Subrahmanyam, A.; Yesilyurt, V.; Thayumanavan, S. “Temperature-Sensitive Transitions Below LCST in Amphiphilic Dendritic Assemblies – Host-Guest Implications” J. Am. Chem. Soc. 2013, 135, 8947-8954. (DOI: 10.1021/ja402019c) (R,S)


Zhuang, J.; Gordon, M.; Ventura, J.; Li, L. Thayumanavan, S. “Multi-Stimuli Responsive Macromolecules and Their Assemblies” Chem. Soc. Rev. 2013, 42, 7421-7435. (DOI: 10.1039/C3CS60094G) (R, S)


González-Toro, D.; Thayumanavan, S. “Advances in Polymer and Polymeric Nanostructures for Protein Conjugation” Eur. Poly. J. 2013, 49, 2906-2918. (DOI: 10.1016/j.eurpolymj.2013.05.002) (R)


Matsumoto, N.; Gonzalez-Toro, D.; Chacko, R.; Maynard, H. D.; Thayumanavan, S. “Synthesis of Nanogel-Protein Conjugates” Polymer Chem. 2013, 4, 2464-2469. (DOI: 10.1039/c3py00085k) (R)


Li, L.; Ryu, J.; Thayumanavan, S. “Effect of Hofmeister Ions on the Size and Encapsulation Stability in Polymer Nanogels” Langmuir, 2013, 29, 50-55. (DOI: 10.1021/la3033463) (R)


Bickerton, S.; Jiwpanich, S.; Thayumanavan, S. “Interconnected Roles of Scaffold Hydrophobicity, Drug Loading and Encapsulation Stability in Polymeric Nanocarriers” Mol. Pharm. 2012, 9, 3569-3578. (DOI: 1021/mp3004226) (R, S)


Gonzalez-Toro, D.; Ryu, J.-H.; Chacko, R.; Zhuang, J.; Thayumanavan, S. “Concurrent Binding and Delivery of Proteins and Lipophilic Small Molecules Using Polymeric Nanogels” J. Am. Chem. Soc. 2012, 134, 6964-6967. (DOI: 10.1021/ja3019143) (R)


Ryu, J.; Bickerton, S.; Zhuang, J.; Thayumanavan, S. “Ligand-Decorated Nanogels: Fast One-Pot Synthesis and Cellular Targeting” Biomacromolecules, 2012, 13, 1515-1522. (DOI: 10.1021/bm300201x) (R)


Chacko, R.; Ventura, J.; Zhuang, J.; Thayumanavan, S. “Polymer Nanogels: A Versatile Nanoscopic Drug Delivery Platform” Adv. Drug Deliv. Rev. 2012, 64, 836-851. (Invited Perspective) (DOI: 10.1016/j.addr.2012.02.002) (R)


Zhuang, J.; Jiwpanich, S.; Deepak, V. D.; Thayumanavan, S. “Facile Preparation of Nanogels Using Activated Ester Containing Polymers” ACS Macro Lett. 2012, 1, 175-179. (DOI: 10.1021/mz200123f) (R)


Ryu, J.-H.; Chacko, R.; Jiwpanich, S.; Bickerton, S.; Babu, R. P.; Thayumanavan, S. “Self-Crosslinked Polymer Nanogels: a Versatile Nanoscopic Drug Delivery Platform” J. Am. Chem. Soc. 2010, 132, 17227-17235. (DOI: 10.1021/ja1069932) (R)


Jiwpanich, S.; Ryu, J.-H.; Bickerton, S.; Thayumanavan, S. “Noncovalent Encapsulation Stability in Supramolecular Nanoassemblies” J. Am. Chem. Soc. 2010, 132, 10683-10685. (DOI: 10.1021/ja105059g) (R, S)


Satav, S.; Bhat, S.; Thayumanavan, S. “Feedback Regulated Drug Delivery Vehicles: Carbon Dioxide Responsive Cationic Hydrogels for Antidote Release” Biomacromolecules, 2010, 11, 1735-1740. (DOI: 10.1021/bm1005454) (R)


Ryu, J.-H.; Jiwpanich, S.; Chacko, R.; Bickerton, S.; Thayumanavan, S. “Surface-Functionalizable Polymer Nanogels with Facile Hydrophobic Guest Encapsulation Capabilities” J. Am. Chem. Soc. 2010, 132, 8246-8247. (DOI: 10.1021/ja102316a) (R)


Ryu, J.; Park, S.; Kim, B.; Klaikherd, A.; Russell, T. P.; Thayumanavan, S. “Highly Ordered Gold Nanotubes using Thiols at a Cleavable Block Copolymer Interface” J. Am. Chem. Soc. 2009, 131, 9870-9871. (DOI: 10.1021/ja902567p) (R)


Roy, R.; Jerry, D. J.; Thayumanavan, S. “Virus-Inspired Approach to Nonviral Gene Delivery Vehicles” Biomacromolecules, 2009, 10, 2189-2193. (DOI: 10.1021/bm900370p) (R)


Klaikherd, A.; Chikkanagari, N.; Thayumanavan, S. “Multi-Stimuli Sensitive Amphiphilic Block Copolymer Assemblies” J. Am. Chem. Soc. 2009, 131, 4830-4838. (DOI: 10.1021/ja809475a) (R)


Ghosh, S.; Yesilyurt, V.; Savariar, E. N.; Irvin, K.; Thayumanavan, S. “Redox, Ionic Strength, and pH Sensitive Supramolecular Polymer Assemblies” J. Poly. Sci. Part A: Poly. Chem. 2009, 47, 1052-1060. (DOI: 10.1002/pola.23204) (R)


Savariar, E. N.; Sochat, M. M.; Klaikherd, A.; Thayumanavan, S. “Functional Group Density and Recognition in Polymer Nanotubes” Angew. Chem. Int. Ed. 2009, 48, 110-114. (DOI: 10.1002/anie.200804136) (R)


Savariar, E. N.; Ghosh, S.; González, D. C.; Thayumanavan, S. “Disassembly of Noncovalent Amphiphilic Polymers with Proteins and Utility in Pattern Sensing” J. Am. Chem. Soc. 2008, 130, 5416-5417.  (DOI: 10.1021/ja800164z) (R, S)


Klaikherd, A.; Ghosh, S.; Thayumanavan, S. “A Facile Method for the Synthesis of Cleavable Block Copolymers from ATRP-based Homopolymers” Macromolecules, 2007, 40, 8518-8520. (DOI: 10.1021/ma071852n) (R, S)


Ghosh, S.; Irvin, K.; Thayumanavan, S. “Tunable Disassembly of Micelles Using a Redox Trigger” Langmuir 2007, 23, 7916-7919. (DOI: 10.1021/la700981z) (R)


Kim, Y.J.; Shin, D.; Vutukuri, D.; Savariar, E.N.; Kim, S.Y.; Thayumanavan, S.; Russell, T.P. “Globular Organization of Multifunctional Linear Homopolymer Using Trifunctional Molecules” Macromolecules, 2007, 40, 4267-4275. (DOI: 10.1021/ma070170x) (R)


Ambade, A. V.; Savariar, E. N.; Thayumanavan, S. “Dendritic Nanostructures for Cancer Therapy” Nanotechnology for Cancer Therapy, 2007, 509-521. (invited review). (DOI: 10.1201/9781420006636.ch26) (R, S)


Ghosh, S.; Basu, S.; Thayumanavan, S. “Simultaneous and Reversible Functionalization of Copolymers for Biological Applications” Macromolecules, 2006, 39, 5595-5597. (DOI: 10.1021/ma061420x) (R, S)


Roy, R.; Sandanaraj, B. S.; Klaikherd, A.; Thayumanavan, S. “Tuning Substrate Selectivity of a Cationic Enzyme Using Cationic Polymers” Langmuir, 2006, 22, 7695-7700. (DOI: 10.1021/la060496j) (R, S)


Jiang, J.; Thayumanavan, S. “Synthesis and Characterization of Amine-Functionalized Polystyrene Nanoparticles” Macromolecules, 2005, 38, 5886-5891. (DOI: 10.1021/ma0507286) (S, R)


Savariar, E. N.; Thayumanavan, S. “Controlled Polymerization of N-isopropylacrylamide with an Activated Methacrylic Ester” J. Poly. Sci. Part A: Poly. Chem. 2004, 42, 6340-6345. (DOI:10.1002/pola.20467) (S, R)


Basu, S.; Vutukuri, D.; Shyamroy, S.; Sandanaraj, B.S.; Thayumanavan, S. “Invertible Amphiphilic Polymers” J. Am. Chem. Soc. 2004, 126, 9890-9891. (DOI: 10.1021/ja047816a) (S, R)