Supramolecular Assembly and Disassembly


Das, R.; Kanjilal, P.; Medeiros, J.; Thayumanavan, S. “What’s Next After LNPs? A Perspective on Enablers of Nucleic Acid Therapeutics” Bioconj. Chem. 2022, 33, In press. (DOI:10.1021/acs.bioconjchem.2c00058)


Singh, K.; Canakci, M.; Kanjilal, P.; Williams, N.; Shanthalingam, S.; Osborne, B.; Thayumanavan, S. “Evaluation of Cellular Targeting by Fab’ vs Full-length Antibodies in Antibody-Nanoparticle Conjugates (ANCs) Using CD4 T-cells” Bioconj. Chem. 2022, 33, In press. (DOI: 10.1021/acs.bioconjchem.2c00024)


Liu, H.; Prachyathipsakul, T.; Koyasseril-Yehiya, T.M.; Le, S.P.; Thayumanavan, S. “Molecular bases for temperature sensitivity in supramolecular assemblies and their applications as thermoresponsive soft materials” Mater. Horiz., 2021, 9, 164-193. (DOI:10.1039/D1MH01091C)


Liu, H.; Kanjilal, P.; Thayumanavan, S. “Self-assembly of Polymers from Multicomponent Reactions” Polymer International, 2022, In Press . (DOI:10.1002/pi.6352)


Wu, P.; Gao, J.; Prasad, P.; Dutta, K.; Kanjilal, P.; Thayumanavan, S. “Influence of Polymer Structure and Architecture on Drug Loading and Redox-Triggered Release” Biomacromolecules, 2021, 23, 1, 339–348 . (DOI:10.1021/jacs.1c08574)


Liu, H.; Lu, H.H.; Zhuang, J.; Thayumanavan, S. “Three-Component Dynamic Covalent Chemistry: From Janus Small Molecules to Functional Polymers” J. Am. Chem. Soc., 2021, 143, 20735-20746. (DOI:10.1021/jacs.1c08574)


Gao, J.*; Prachyathipsakul, T.*; Thayumanavan, S. “Multichannel Dual Protein Sensing Using Amphiphilic Supramolecular Assemblies” Chem. Commun., 2021, 57, 12828-12831. (DOI:10.1039/D1CC05407D)


Gao, J.; Le, S.; Thayumanavan, S. “Enzyme Catalysis in Non-Native Environment with Unnatural Selectivity using Polymeric Nanoreactors” Angew. Chem. Int. Ed., 2021, 60, 27189–27194. (DOI:10.1002/anie.202109477)


Lionello, C.; Gardin, A.; Cardellini, A.; Bochicchio, D.; Shivrayan, M.; Fernandez, A.; Thayumanavan, S.; and Pavan, G.M. “Toward Chemotactic Supramolecular Nanoparticles: From Autonomous Surface Motion Following Specific Chemical Gradients to Multivalency-Controlled Disassembly” ACS Nano, 2021, 15, 10, 16149-16161 . (DOI:10.1021/acsnano.1c05000)


Nandi, D.; Shivrayan, M.; Gao, J.; Krishna, J.; Das, R.; Liu, B.; Thayumanavan, S.; and Kulkarni, A. “Core Hydrophobicity of Supramolecular Nanoparticles Induces NLRP3 Inflammasome Activation” ACS Appl. Mater. Interfaces, 2021, 13, 38, 45300-45314. (DOI:10.1021/acsami.1c14082)


Liu, H.; Westley, J.; Thayumanavan, S. “Excimer-monomer fluorescence changes by supramolecular disassembly for protein sensing and quantification” Chem. Commun., 2021, 57, 9776-9779. (DOI:10.1039/D1CC03944J)


Anson, F.; Thayumanavan, S.; Hardy, J.A. “Exogenous Introduction of Initiator and Executioner Caspases Results in Different Apoptotic Outcomes” JACS Au, 2021,1, 8, 1240–1256 . (DOI:10.1021/jacsau.1c00261)


Dutta, K.; Das, R.; Medeiros, J.; Kanjilal, K.; Thayumanavan, S.“Charge-Conversion Strategies for Nucleic Acid Delivery” Adv. Funct. Mater., 2021, 31, 2011103. (DOI:10.1002/adfm.202011103)


Liu, H.; Lionello, C.; Westley, J.; Cardellini, A.; Huynh, U.; Pavan, G.M.; Thayumanavan, S. “Understanding functional group and assembly dynamics in temperature responsive systems leads to design principles for enzyme responsive assemblies” Nanoscale, 2021 , 13, 11568-11575 . (DOI:10.1039/D1NR02000E)


Liu, B.; Singh, K.; Gong, S.; Canakci, M.; Osborne, B.A.; Thayumanavan, S. “Protein-Antibody Conjugates (PACs): A Plug-and-Play Strategy for Covalent Conjugation and Targeted Intracellular Delivery of Pristine Proteins” Angew. Chemie. Int. Ed., 2021 , 60, 12813-12818 . (DOI:10.1002/anie.202103106)


Anson, F.; Liu, B.; Kanjilal, P.; Wu, P.; Hardy, J. A.; Thayumanavan, S. “Evaluating Endosomal Escape of Caspase-3-Containing Nanomaterials Using Split GFP” Biomacromolecules, 2021 ,22, 3, 1261–1272 . (DOI:10.1021/acs.biomac.0c01767)


Dutta, K.; Das, R.; Medeiros, J. M.; Thayumanavan, S. “”Disulfide Bridging Strategies in Viral and Non-viral Platforms for Nucleic Acid Delivery” Biochemistry, 2021, 60, 13, 966–990. (DOI:10.1021/acs.biochem.0c00860)


Anson, F.; Kanjilal, P.; Thayumanavan, S.; Hardy, J. “Tracking Exogenous Intracellular Casp-3 Using Split GFP” Prot. Sci., 2020, 30 , 366-380 . (DOI:10.1002/pro.3992)


Dutta, K.; Kanjilal, P.; Das, R.; Thayumanavan, S. “Synergistic Interplay of Covalent and Non-Covalent Interactions in Reactive Polymer Nanoassembly Facilitates Intracellular Delivery of Antibodies” Angew. Chem. Int. Ed., 2020, 59, 2-12 . (DOI: 10.1002/anie.202010412)


Koyasseril-Yehiya, T. M.; García-Heredia, A.; Anson, F.; Rangadurai, P.; Siegrist, M. S.; Thayumanavan, S. “Supramolecular Antibiotics: A Strategy for Conversion of Broad-Spectrum to Narrow-Spectrum Antibiotics for Staphylococcus aureus” Nanoscale, 2020, 12, 20693-20698 . (DOI: 10.1039/D0NR04886K)


Gao, J.; Dutta, K.; Zhuang, J.; Thayumanavan, S. “Cellular and subcellular targeted delivery using a simple all-in-one polymeric nanoassembly” Angew. Chem. Int. Ed., 2020, 59, 23466-23470 . (DOI: 10.1002/anie.202008272)


Kumar, V.; Munkhbat, O.; Secinti, H.; Thayumanavan, S “Disassembly of Polymeric Nanoparticles with Enzyme-Triggered Polymer Unzipping: Polyelectrolyte Complexes vs. Amphiphilic Nanoassemblies” Chem. Commun., 2020, 56, 8456-8459 . (DOI: 10.1039/D0CC03257C)


Dutta, K.; Das, R.; Ling, J.; Monibas, R.M.; Carballo-Jane, E.; Kekec, A.; Feng, D.D.; Lin, S.; Mu, J.; Saklatvala, R.; Thayumanavan, S.; Liang, Y. “In Situ Forming Injectable Thermoresponsive Hydrogels for Controlled Delivery of Biomacromolecules” ACS Omega, 2020, 5, 17531-17542 . (DOI: 10.1021/acsomega.0c02009)


Zhuang, J. and Thayumanavan, S. “Triblock–Diblock Composite Nanoassemblies with Sequentially Addressable Host–Guest Properties for Hydrophobics and Hydrophilics” ACS Macro Lett, 2020, 9, 1019-1023 . (DOI: 10.1021/acsmacrolett.0c00290)


Liu, B.; Wu, R.; Gong, S.; Xiao, H.; Thayumanavan, S. “In Situ Formation of Polymeric Nanoassemblies Using an Efficient reversible Click Reaction” Angew. Chem. Int. Ed., 2020, 59, 15135 –15140 . (DOI: 10.1002/anie.202004017)


Canakci, M.; Singh, K.; Munkhbat, O.; Santhalingam, S.; Mitra, A.; Gordon, M.; Osborne, B.; Thayumanavan, S. “Targeting CD4+ Cells with Anti-CD4 Conjugated mertansine Loaded Nanogels” Biomacromolecules, 2020, 21, 2473–2481 . (DOI: 10.1021/acs.biomac.0c00442)


Liu, B.; Ejaz, W.; Gong, S.; Kurbanov, M.; Canakci, M.; Anson, F.; Thayumanavan, S. ” Engineered Interactions with Mesoporous Silica Facilitate Intracellular Delivery of Proteins and Gene Editing” Nano Lett., 2020, 20, 4014-4021 (DOI: 10.1021/acs.nanolett.0c01387)


Zhao, B.; Zhuang, J.; Xu, M.; Liu, T.; Limpikirati, P.; Thayumanavan, S.; Vachet, R.W. “Covalent Labeling with an α, β Unsaturated Carbonyl Scaffold for Studying Protein Structure and Interactions by Mass Spectrometry” Anal. Chem., 2020, 92, 6637−6644 . (DOI: 10.1021/acs.analchem.0c00463 )


Mitra, A.; Shanthalingam, S.; Sherman, H.; Singh, K.; Canakci, M.; Torres, J.A.; Lawlor, R.; Ran, Y.; Golde, T.; Miele, L.; Thayumanavan, S.; Minter, L.M.; Osborne, B.A. “Regulation of Notch ligand expression on CD4 T cells” Frontiers in Immunology, 2020, 11, 735 . (DOI: 10.3389/fimmu.2020.00735)


Jiang, Z.; Liu, H.; He, H.; Yadava, N.; Chambers, J. “Anionic Polymers Promote Mitochondrial Targeting of Delocalized Lipophilic Cations” Bioconjugate Chem., 2020, 31, 1344–1353. (DOI: 10.1021/acs.bioconjchem.0c00079)
[Video] [Featured as the Cover Art]


Gao, J.; Wu, P.; Fernandez, A.; Zhuang, J.; Thayumanavan, S. “Cellular AND Gates: Synergistic Recognition to Boost Selective Uptake of Polymeric Nanoassemblies” Angew.Chem.Int.Ed., 2020, 59, 1-6. (DOI: 10.1002/anie.202002748)


Jiang, Z.; Liu, H. (co-first); He, H.; Ribbe, A.E.; Thayumanavan, S. “Blended Assemblies of Amphiphilic Random and Block Copolymers for Tunable Encapsulation and Release of Hydrophobic Guest Molecules” Macromolecules, 2020, 53, 2713–2723 . (DOI: 10.1021/acs.macromol.9b02595)


Tsuei, M.; Shivrayan, M.; Kim, Y.; Thayumanavan, S.; Abbott, N.L. “Optical “Blinking” Triggered by Collisions of Single Supramolecular Assemblies of Amphiphilic Molecules with Interfaces of Liquid Crystals” J. Am. Chem. Soc., 2020, 142, 6139–6148 . (DOI: 10.1021/jacs.9b13360)


Jiang, Z. and Thayumanavan, S. “Disulfide‐containing Macromolecules for Therapeutic Delivery” Isr. J. of Chem., 2020, 60, 132-139. (DOI: 10.1002/ijch.201900160)


Jiang, Z. and Thayumanavan, S. “Noncationic Material Design for Nucleic Acid Delivery” Advanced Therapeutics, 2020 ,1900206 . (DOI: 10.1002/adtp.201900206)


Zhao, B.; Gao, J.; Serrano, M.A.C.; Arcaro, K.F.; Thayumanavan, S.; and Vachet, R.W. “Polymeric nanoassemblies for enrichment and detection of peptides and proteins in human breast milk” Anal Bioanal Chem, 2020, 412, 1027-1035. (DOI: 10.1007/s00216-019-02342-8)


Jiang, Z.; He, H.; Liu, H.; Thayumanavan, S. “Cellular Uptake Evaluation of Amphiphilic Polymer Assemblies: Importance of Interplay between Pharmacological and Genetic Approaches” Biomacromolecules, 2019, 20, 4407-4418 . (DOI: 10.1021/acs.biomac.9b01073)


Wang, M.; Gao, J.; Zhao, B.; Thayumanavan, S.and Vachet, R.W. “Efficient enrichment of glycopeptides by supramolecular nanoassemblies that use proximity-assisted covalent binding” Analyst, 2019, 144, 6321-6326 . (DOI: 10.1039/C9AN01113G)


Liu, B. and Thayumanavan, S. “Three-Component Sequential Reactions for Polymeric Nanoparticles with Tailorable Core and Surface Functionalities” Chem, 2019, 5, 3166-3183 . (DOI: 10.1016/j.chempr.2019.09.001)


Liu, B.; Ianosi-Irimie, M.; Thayumanavan, S. “Reversible Click Chemistry for Ultrafast and Quantitative Formation of Protein-Polymer Nanoassembly and Intracellular Protein Delivery” ACS Nano, 2019, 13, 9408-9420 . (DOI: 10.1021/acsnano.9b04198)


Dutta, K.; Bochicchio, D.; Ribbe, A.E.; Alfandari, D.; Mager, J.; Pavan, G.M.; Thayumanavan, S. “Symbiotic Self-Assembly Strategy toward Lipid-Encased Cross-Linked Polymer Nanoparticles for Efficient Gene Silencing” ACS Appl. Mater. Interfaces 2019, 11, 24971-24983 . (DOI: 10.1021/acsami.9b04731)


Raghupathi, K.; Kumar, V.; Sridhar, U.; Ribbe, A.E.; He, H.; Thayumanavan, S. “Role of Oligoethylene Glycol Side Chain Length in Responsive Polymeric Nanoassemblies” Langmuir, 2019, 35, 7929-7936 . (DOI: 10.1021/acs.langmuir.9b00676)


Singh, K.; Ejaz, W.; Dutta, K.; Thayumanavan, S. “Antibody Delivery for Intracellular Targets – Emergent Therapeutic Potential” Bioconjugate Chem. 2019, 30, 1028-1041. (DOI: 10.1021/acs.bioconjchem.9b00025)


Khomein, P.; Dutta, K.; Gnanasekaran, K.; Gianneschi, N. C.; Thayumanavan, S. “Spatiotemporal Control over the Host–guest Characteristics of a Stimulus-triggerable Trifunctional Polymer Assembly” Polym. Chem. 2019, 10, 1423-1430 . (DOI: 10.1039/C8PY01788C)


Gao, J.; Wang, H.; Zhuang, J.; Thayumanavan, S. “Tunable Enzyme Responses in Amphiphilic Nanoassemblies through Alterations in the Unimer–aggregate Equilibrium” Chem. Sci. 2019, 10, 3018-3024. (DOI: 10.1039/C8SC04744H)


Jiang, Z.; Cui, W.; Prasad, P.; Touve, M. A.; Gianneschi, N. C.; Mager, J.; Thayumanavan, S. “Bait-and-Switch Supramolecular Strategy To Generate Noncationic RNA–Polymer Complexes for RNA Delivery” Biomacromolecules 2019, 20, 435–442. (DOI: 10.1021/acs.biomac.8b01321)


He, H.; Liu, B.; Wang, M.; Vachet, R. W.; Thayumanavan, S. “Sequential Nucleophilic ‘Click’ Reactions for Functional Amphiphilic Homopolymers” Polym. Chem. 2019, 10, 187-193. (DOI: 10.1039/C8PY01341A)


Zhuang, J.; Secinti, H.; Zhao, B.; Thayumanavan, S. “Propagation of Enzyme Induced Surface Events Inside Polymer Nanoassemblies for a Fast and Tunable Response” Angew. Chem. Int. Ed. 2018, 57, 7111-7115. (DOI: 10.1002/anie.201803029)


Molla, M. R.; Rangadurai, P.; Antony, L.; Swaminathan, S.; de Pablo, J. J.; Thayumanavan, S. “Dynamic Actuation of Glassy Polymersomes through Isomerization of a Single Azobenzene Unit at the Block Copolymer Interface” Nat. Chem. 2018, 10, 659–666. (DOI: 10.1038/s41557-018-0027-6)
[Highlighted by UMass News]


Serrano, M. A. C.; Gao, J.; Kelly, K. A.; Thayumanavan, S.; Vachet, R. W. “Supramolecular Polymeric Assemblies for the Selective Depletion of Abundant Acidic Proteins in Serum” ACS Appl. Mater. Interfaces 2018, 10, 40443–40451. (DOI: 10.1021/acsami.8b15976)


Kim, Y.-K.; Raghupathi, K. R.; Pendery, J. S.; Khomein, P.; Sridhar, U.; de Pablo, J. J.; Thayumanavan, S.; Abbott, N. L. “Oligomers as Triggers for Responsive Liquid Crystals” Langmuir 2018, 34, 10092–10101. (DOI: 10.1021/acs.langmuir.8b01944)


Leriche, G.; Manafirad, A.; Nguyen, S.; Bell, N.; Patterson, J. P.; Thayumanavan, S.; Yang, J.; Dinsmore, A. D.; Gianneschi, N. C. “Water Permeability and Elastic Properties of an Archaea Inspired Lipid Synthesized by Click Chemistry” Chem. Mater. 2018, 30, 3618–3622. (DOI: 10.1021/acs.chemmater.8b00992)


Serrano, M. A. C.; Zhao, B.; He, H.; Thayumanavan, S.; Vachet, R. W. “Molecular Features Influencing the Release of Peptides from Amphiphilic Polymeric Reverse Micelles” Langmuir 2018, 34, 4595–4602. (DOI: 10.1021/acs.langmuir.7b04065)


Zhao, B.; Serrano, M. A. C.; Wang, M.; Liu, T.; Gordon, M. R.; Thayumanavan, S.; Vachet, R. W. “Improved Mass Spectrometric Detection of Acidic Peptides by Variations in the Functional Group pKa Values of Reverse Micelle Extraction Agents” Analyst 2018, 143, 1434-1443. (DOI: 10.1039/C7AN02094E)


Gao, J.; Zhao, B.; Wang, M.; Serrano, M. A. C.; Zhuang, J.; Ray, M.; Rotello, V. M.; Vachet, R. W.; Thayumanavan, S. “Supramolecular Assemblies for Transporting Proteins Across an Immiscible Solvent Interface” J. Am. Chem. Soc. 2018, 7, 2421-2425. (DOI: 10.1021/jacs.7b13245)


Gao, J.; Liu, X.; Secinti, H.; Jiang, Z.; Munkhbat, O.; Xu, Y.; Guo, X.; Thayumanavan, S. “Photoactivation of Ligands for Extrinsically and Intrinsically Triggered Disassembly of Amphiphilic Nanoassemblies” Chem. Eur. J. 2018, 24, 1789–1794. (DOI: 10.1002/chem.201705217)


Zhao, B.; Serrano, M. A. C.; Gao, J.; Zhuang, J.; Vachet, R. W.; Thayumanavan, S. “Self-assembly of Random Co-polymers for Selective Binding and Detection of Peptides” Polym. Chem. 2018, 9, 1066-1071. (DOI: 10.1039/C7PY01947E)


Homyak, C. C.; Fernandez, A.; Touve, M. A.; Zhao, B.; Anson, F.; Hardy, J. A.; Vachet, R. W.; Gianneschi, N. C.; Ross, J. L.; Thayumanavan, S. “Lipogels for Encapsulation of Hydrophilic Proteins and Hydrophobic Small Molecules” Biomacromolecules 2018, 19, 132–140. (DOI: 10.1021/acs.biomac.7b01300)


Khomein, P.; Swaminathan, S.; Young, E. R.; Thayumanavan, S. “Fluorescence Enhancement Through Incorporation of Chromophores in Polymeric Nanoparticles” J. Inorg. Organomet. Polym. Mater. 2018, 28, 407-413. (DOI: 10.1007/s10904-017-0670-1)


Zhao, B.; Zhuang, J.; Serrano, M. A. C.; Vachet, R. W.; Thayumanavan, S. “Influence of Charge Density on Host–Guest Interactions within Amphiphilic Polymer Assemblies in Apolar Media” Macromolecules 2017, 50, 9734–9741. (DOI: 10.1021/acs.macromol.7b02434)


Liu, B.; Thayumanavan, S. “Importance of Evaluating Dynamic Encapsulation Stability of Amphiphilic Assemblies in Serum” Biomacromolecules 2017, 18, 4163–4170. (DOI: 10.1021/acs.biomac.7b01220)


Wang, M.; Zhao, B.; Gao, J.; He, H.; Castellanos, L. J.; Thayumanavan, S.; Vachet, R. W. “Altering the Peptide Binding Selectivity of Polymeric Reverse Micelle Assemblies via Metal Ion Loading” Langmuir 2017, 33, 14004–14010. (DOI: 10.1021/acs.langmuir.7b02488)
[Featured as cover image, ACS Editors’ Choice]


Dutta, K.; Hu, D.; Zhao, B.; Ribbe, A.; Zhuang, J.; Thayumanavan, S. “Templated Self-Assembly of a Covalent Polymer Network for Intracellular Protein Delivery and Traceless Release” J. Am. Chem. Soc. 2017, 139, 5676–5679. (DOI: 10.1021/jacs.7b01214)
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Khomein, P.; Thayumanavan, S. “Effect of Incorporating Flat Aromatic Molecules on Spherical Polymeric Nanoparticles” Chem. Commun. 2017, 53, 5190-5192. (DOI: 10.1039/C7CC00963A)


Zhuang, J.; Garzoni, M.; Torres, D. A.; Poe, A.; Pavan, P. M.; Thayumanavan, S. “Programmable Nanoassemblies from Non-Assembling Homopolymers Using Ad Hoc Electrostatic Interactions” Angew. Chem. Int. Ed. 2017, 56, 4145–4149. (DOI: 10.1002/anie.201611688)


Serrano, M. A. C.; He, H.; Zhao, B.; Ramireddy, R. R.; Vachet, R. W.; Thayumanavan, S. “Polymer-Mediated Ternary Supramolecular Interactions for Sensitive Detection of Peptides” Analyst 2017, 142, 118–122. (DOI: 10.1039/C6AN01591C)


Homyak, C.; Anson. F.; Thayumanavan, S. “Supramolecular Polymers in Nanomedicine” Comprehensive Supramolecular Chemistry II, 2016, Elsevier Inc. Ed. J. W. Atwood. (DOI: 10.1016/B978-0-12-409547-2.12566-1)


Liu, X.; Ding, H.; Jiang, Z.; Zhuang, J.; Xu, Y.; Guo, X.; Thayumanavan, S. “Multi-Stimuli-Responsive Amphiphilic Assemblies through Simple Postpolymerization Modifications” Macromolecules 2016, 49, 6186–6192. (DOI: 10.1021/acs.macromol.6b01397)


Bai, W.; Jiang, Z.; Ribbe, A. E.; Thayumanavan, S. “Smart Organic Two-Dimensional Materials Based on a Rational Combination of Non-covalent Interactions” Angew. Chem. Int. Ed. 2016, 55, 10707–10711. (DOI: 10.1002/anie.201605050)


Munkhbat, O.; Garzoni, M.; Raghupathi, K. R.; Pavan, G. M.; Thayumanavan, S. “Role of Aromatic Interactions in Temperature-Sensitive Amphiphilic Supramolecular Assemblies” Langmuir 2016, 32, 2874–2881. (DOI: 10.1021/acs.langmuir.5b04540)


Wang, H.; Zhuang, J.; Raghupathi, K. R.; Thayumanavan, S. “A Supramolecular Dissociation Strategy for Protein Sensing” Chem. Commun. 2015, 51, 17265–17268. (DOI: 10.1039/C5CC07408H)


Prasad, P.; Molla, M. R.; Cui, W.; Canakci, M.; Osborne, B.; Mager, J.; Thayumanavan, S. “Polyamide Nanogels from GRAS Components and Their Toxicity in Mouse Pre-implantation Embryos” Biomacromolecules 2015, 16, 3491–3498. (DOI: 10.1021/acs.biomac.5b00900)


Li, L.; Yuan, C.; Chen, D.; Ribbe, A. E.; Kittilstved, K. Thayumanavan, S. “Utilizing Reversible Interactions in Polymeric Nanoparticles to Generate Hollow Metal Organic Nanoparticles” Angew. Chem. Int. Ed. 2015, 54, 12991–12995. (DOI: 10.1002/anie.201505242)


Ventura, J.; Eron, S. J.; González-Toro, D. C.; Raghpathi, K. R.; Wang, F.; Hardy, J. A.; Thayumanavan, S. “Reactive Self-Assembly of Polymers and Proteins to Reversibly Silence a Killer Protein” Biomacromolecules 2015, 16, 3161–3171. (DOI: 10.1021/acs.biomac.5b00779)


Bell, N. C.; Doyle, S. J.; Battistelli, G.; LeGuyader, C. L. M.; Thompson, M. P.; Poe, A.; Montalti, M.; Thayumanavan, S.; Tauber, M. J.; Gianneschi, N. C. “Dye Encapsulation in Polybornene Micelles” Langmuir 2015, 31, 9707–9717. (DOI: 10.1021/acs.langmuir.5b01822)


Ramireddy, R. R.; Prasad, P.; Fine, A.; Thayumanavan, S. “Zwitterionic Amphiphilic Homopolymer Assemblies” Polym. Chem. 2015, 6, 6083-6087. (DOI: 10.1039/C5PY00879D)


Molla, M. R.; Prasad, P.; Thayumanavan, S. “Protein‐Induced Supramolecular Disassembly of Amphiphilic Polypeptide Nanoassemblies” J. Am. Chem. Soc. 2015, 137, 7286-7289. (DOI: 10.1021/jacs.5b04285) (R,S)170


Raghupathi, K. R.; Sridhar, U.; Byrne, K.; Raghupathi, K. R.; Thayumanavan, S. “Influence of Backbone Conformational Rigidity in Temperature-Sensitive Amphiphilic Supramolecular Assemblies” J. Am. Chem. Soc. 2015, 137, 5308-5311 (DOI: 10.1021/jacs.5b02108). (R, S)168


Wang, Hui; Raghupathi, K.; Zhuang, J.; Thayumanavan, S. “Activatable Dendritic 19F Probes for Enzyme Detection” ACS Macro Letters, 2015, 4, 422-425 (DOI: 10.1021/acsmacrolett.5b00199). (R, S)167


Yuan, C.; Chang, Y.; Mao, J.; Yu, S.; Luo, W.; Xu, Y.; Thayumanavan, S.; Dai, L. “Supramolecular Assembly of Crosslinkable Monomers for Degradable and Fluorescent Polymer Nanoparticles” J. Mater. Chem. B. , 2015, 2858-2866  (DOI: 10.1039/c4tb01880j).  (R,S)





Molla, M. R.; Rangadurai, P.; Pavan, G. M.; Thayumanavan, S. “Experimental and Theoretical Investigations in Stimuli Responsive Dendrimer-based Assemblies” Nanoscale, 2015, 7, 3817-3837 (DOI: 10.1039/C4NR04563G). (R,S)



Molla, M. R.; Marcinko, T.; Prasad, P.; Deming, D.; Garman, S.; Thayumanavan, S. “Unlocking a Caged Lysosomal Protein from a Polymeric Nanogel with a pH Trigger” Biomacromolecules, 2014, 15, 4046-4053 (DOI: 10.1021/bm501091p). (R,S)



Li, L.; Thayumanavan, S. “Environment-Dependent Guest-Exchange in Supramolecular Hosts” Langmuir, 2014, 30, 12384-12390 (DOI: 10.1021/la502760c). (R,S)



Li, L.; Yuan, C.; Dai, L.; Thayumanavan, S. “Thermo-responsive Polymeric Nanoparticles: Nucleation from Cooperative Polymerization Driven by Dative Bonds” Macromolecules, 2014, 47, 5869-5876 (DOI: 10.1021/ma5015808). (R,S)



Li, L; Raghupathi, K. R.; Song, C.; Prasad, P.; Thayumanavan, S. “Self-assembly of Random Copolymers”  Chem. Commun., 2014, 50, 13417-13432, (Invited Review), DOI: 10.1039/C4CC03688C. (S)



Raghupathi, K.; Guo, J.; Munkhbat, O.; Rangadurai, P.; Thayumanavan, S. “Supramolecular Assembly and Disassembly of Facially Amphiphilic Dendrimers” Acc. Chem. Res. 201447, 2200-2211 (Invited Review)  (DOI: 10.1021/ar500143u) (PMCID# PMC4100797). (R,S)



Amado Torres, D.; Garzoni, M.; Subrahmanyam, A.; Pavan, G. M.; Thayumanavan, S. “Protein-Triggered Supramolecular Disassembly: Insights Based on Variations in Ligand Location in Amphiphilic Dendrons” J. Am. Chem. Soc. 2014, 136, 5385-5399. (DOI: 10.1021/ja500634u ) (R,S) 155


Guo, J.; Zhuang, J.; Wang, F.; Raghupathi, K.; Thayumanavan, S. “Protein AND Enzyme Gated Supramolecular Disassembly”  J. Am. Chem. Soc. 2014, 136, 2220-2223   (DOI: 10.1021/ja4108676) (R,S). 



Zhuang, J.; Chacko, R.; Amado Torres, D.; Wang, H.; Thayumanavan, S. “Dual Stimuli – Dual Response Nanoassemblies Prepared from a Simple Homopolymer” ACS Macro Lett. 2014, 3, 1-5 (DOI: 10.1021/mz400515s) (R,S).



Raghupathi, K.; Li, L.; Ventura, J.; Jennings, M.; Thayumanavan, S. “pH Responsive Soft Nanoclusters with Size and Charge Conversional Features” Polym. Chem. 2014, 5, 1737-1742. (DOI:10.1039/C3PY01277H) (R,S)



Yuan, C.; Raghupathi, K.; Popere, B. C.; Ventura, J.; Dai, L.; Thayumanavan, S. “Composite Supramolecular Nanoassemblies with Independent Stimulus Sensitivities”  Chem. Sci. 2014, 5, 229-234. (DOI:10.1039/C3SC52347K) (R,S)




Wang, H.; Zhuang, J.; Thayumanavan, S. ““Functionalizable Amine-based Polymer Nanoparticles” ACS Macro Lett. 2013, 2, 948-951. (DOI: 10.1021/mz4004248) (R,S)



Wang, F.; Gomez-Escudero, A.; Ramireddy, R. R.; Murage, G.; Thayumanavan, S.; Vachet, R. W. “Electrostatic Control of Peptide Side-Chain Reactivity using Amphiphilic Homopolymer-based Supramolecular Assemblies” J. Am. Chem. Soc. 2013, 135, 14179-14188. (DOI: 10.1021/ja404940s) (S)



Ramireddy, R.; Subrahmanyam, A.; Thayumanavan, S. “Zwitterionic Moieties from the Huisgen Reaction-A Case Study with Amphiphilic Dendritic Assemblies” Chem. Eur. J., 2013, 19, 16374-16381. (S)



Li, L.; Raghupathi, K.; Yuan, C.; Thayumanavan, S. “Surface Charge Generation in Nanogels for Activated Cellular Uptake at Tumor-Relevant pH” Chem. Sci. 2013, 4, 3654-3660. (DOI: 10.1039/C3SC50899D) (R,S)144



Fuller, J.; Raghupathi, K.; Ramireddy, R. R.; Subrahmanyam, A.; Yesilyurt, V.; Thayumanavan, S. “Temperature-Sensitive Transitions Below LCST in Amphiphilic Dendritic Assemblies – Host-Guest Implications” J. Am. Chem. Soc. 2013, 135, 8947-8954. (DOI: 10.1021/ja402019c) (R,S)


Zhuang, J.; Gordon, M.; Ventura, J.; Li, L. Thayumanavan, S. “Multi-Stimuli Responsive Macromolecules and Their Assemblies” Chem. Soc. Rev. 2013, 42, 7421-7435. (DOI: 10.1039/C3CS60094G) (R, S)


Bickerton, S.; Jiwpanich, S.; Thayumanavan, S. “Interconnected Roles of Scaffold Hydrophobicity, Drug Loading and Encapsulation Stability in Polymeric Nanocarriers” Mol. Pharm. 2012, 9, 3569-3578. (DOI: 1021/mp3004226) (R, S)


Siripornnopakhun, W.; Niamnont, N.; Krumsri, A.; Tumcharern, G.; Vilaivan, T.; Rashatasakhon, P.; Thayumanavan, S.; Sukwattanasinitt, M. “Inclusion Complexes between Amphiphilic Phenylene-Ethynylene Fluorophores and Cyclodextrins in Aqueous Media” J. Phys. Chem. B. 2012, 116, 12268-12274. (DOI: 10.1021/jp3057652) (S)


Amado Torres, D.; Azagarsamy, M.; Thayumanavan, S. “Supramolecular Displacement-Mediated Activation of a Silent Fluorescence Probe for Label-free Ligand Screening” J. Am. Chem. Soc. 2012, 134, 7235-7237. (DOI: 10.1021/ja301204z) (S)


Ramireddy, R.; Raghupathi, K. R.; Torres, D. A.; Thayumanavan, S. “Stimuli Sensitive Amphiphilic Dendrimers” New J. Chem. 2012, 26, 340-349. (Invited Perspective). (DOI: 10.1039/C2NJ20879B) (S)


Rodthongkum, N.; Ramireddy, R.; Thayumanavan, S.; Vachet, R. W. “Selective Enrichment and Sensitive Detection of Peptide and Protein Biomarkers in Human Serum Using Polymeric Reverse Micelles and MALDI-MS” Analyst 2012, 137, 1024-1030. (DOI: 10.1039/C2AN16089G) (S)


Yesilyurt, V.; Ramireddy, R.; Azhagarsamy, M. A.; Thayumanavan, S. “Accessing Lipophilic Ligands in Dendrimer-based Amphiphilic Supramolecular Assemblies for Protein-Induced Disassembly” Chem. Eur. J. 2012, 18, 223-229. (DOI: 10.1002/chem.201102727) (S)


Wang, F.; Klaikherd, A.; Thayumanavan, S. “Temperature Sensitivity Trends and Multi-Stimuli-Sensitive Behavior in Amphiphilic Oligomers” J. Am. Chem. Soc. 2011, 133, 13496-13503. (DOI: 10.1021/ja204121a) (S)


Raghupathi, K. R.; Azagasarmy, M. A.; Thayumanavan, S. “Guest Release Control in Enzyme-Sensitive Amphiphilic Dendrimer-based Nanoparticles through Photochemical Crosslinking” Chem. Eur. J. 2011, 17, 11752-11760. (DOI: 10.1002/chem.201101066) (S)


Nagamani, C.; Viswanathan, U.; Versek, C.; Tuominen, M.; Auerbach, S. M.; Thayumanavan, S. “”Importance of Dynamic Hydrogen Bonds and Reorientation Barriers in Proton Transport” Chem. Commun. 2011, 47, 6638-6640. (DOI: 10.1039/C1CC11207D) (E, S)


Yesilyurt, V.; Ramireddy, R.; Thayumanavan, S. “Photo-Regulated Release of Non-covalent Guests from Dendritic Amphiphilic Nanocontainers” Angew. Chem. It. Ed. 2011, 50, 3038-3042. (DOI: 10.1002/anie.201006193) (S)


Jiwpanich, S.; Ryu, J.-H.; Bickerton, S.; Thayumanavan, S. “Noncovalent Encapsulation Stability in Supramolecular Nanoassemblies” J. Am. Chem. Soc. 2010, 132, 10683-10685. (DOI: 10.1021/ja105059g) (R, S)


Rodthongkum, N.; Chen, Y.; Thayumanavan, S.; Vachet, R. W. “Selective Enrichment and Analysis of Acidic Peptides and Proteins Using Polymeric Reverse Micelles and MALDI-MS” Anal. Chem. 2010, 82, 8686-8691. (DOI: 10.1021/ac101922b) (S)


Rodthongkum, N.; Chen, Y.; Thayumanavan, S.; Vachet, R. W. “MALDI-MS Signal Enhancement of Peptides after Selective Extraction with Polymeric Reverse Micelles” Anal. Chem. 2010, 82, 3686-3691. (DOI: 10.1021/ac1000256) (S)


Azagarsamy, M.; Yesilyurt, V.; Thayumanavan, S. “Disassembly of Dendritic Micellar Containers due to Protein Binding” J. Am. Chem. Soc. 2010, 132, 4550-4551. (DOI: 10.1021/ja100746d) (S)


Chen, Y.; Thorn, M.; Christensen, S.; Versek, C.; Poe, A.; Hayward, R. C.; Tuominen, M. T.; Thayumanavan, S. “Enhancement of Anhydrous Proton Transport by Supramolecular Nanochannels in Comb Polymers” Nature Chem. 2010, 2, 503-508. (DOI: 10.1038/nchem.629) (E, S)


Ryu, J.; Roy, R.; Ventura, J.; Thayumanavan, S. “Redox-Sensitive Disassembly of Amphiphilic Copolymer Based Micelles” Langmuir, 2010, 26, 7086-7092. (DOI: 10.1021/la904437u) (S)


Azagarsamy, M.; Krishnamoorthy, K.; Sivanandan, K.; Thayumanavan, S. “Site-specific Installation and Study of Electroactive Units in Every Layer of Dendrons” J. Org. Chem. 2009, 74, 9475-9485. (DOI: 10.1021/jo902109u) (S)


Azagarsamy, M.; Sokkalingam, P.; Thayumanavan, S. “Enzyme Triggered Disassembly of Dendrimer-based Amphiphilic Nanocontainers” J. Am. Chem. Soc. 2009, 131, 14184-14185. (DOI: 10.1021/ja906162u) (S)


Azagarsamy, M.; Thayumanavan, S. “Magnetic Resonance Imaging: Making Sense of Disassembly” Nature Chemistry, 2009, 1, 523-524. (DOI:10.1038/nchem.383) (S)


Chen, Y.; Thayumanavan, S. “Amphiphilicity in Homopolymer Surfaces Reduces Non-specific Protein Adsorption” Langmuir, 2009, 25, 13795-13799 (Invited manuscript for the 25th year anniversary of Langmuir). (DOI: 10.1021/la901692a) (S)


Rodthongkum, N.; Washington, J. D.; Savariar, E. N.; Thayumanavan, S.; Vachet, R. W. “Generating Peptide Titration-type Curves Using Polymeric Reverse Micelles as Selective Extraction Agents Along with MALDI-MS Detection” Anal. Chem. 2009, 81, 5046-5053. (DOI: 10.1021/ac900661e) (S)


Kale, T.; Klaikherd, A.; Popere, B.; Thayumanavan, S. “Supramolecular Assemblies of Amphiphilic Homopolymers” Langmuir, 2009, 25, 9660-9670 (Invited Feature Article). (DOI:10.1021/la900734d) (S)


González, D. C; Savariar, E. N.; Thayumanavan, S. “Fluorescence Patterns from Supramolecular Polymer Assembly and Disassembly for Sensing of Metallo- and Non-metalloproteins” J. Am. Chem. Soc. 2009, 131, 7708-7716. (DOI: 10.1021/ja900579g) (S)


Azagarsamy, M.A.; Gomez-Escudero, A.; Yesilyurt, V.; Vachet, R.W.; Thayumanavan, S. “Amphiphilic Nanoassemblies for the Detection of Peptides and Proteins Using Fluorescence and Mass Spectrometry” Analyst, 2009, 134, 635-649 (Invited Review). (DOI: 10.1039/B818484D) (S)


Jiwpanich, S.; Sandanararj, B. S.; Thayumanavan, S. “Fluorophore-Cored Dendrimers for Patterns in Metalloprotein Sensing” Chem. Commun. 2009, 806-808. (DOI: 10.1039/B815263B) (S)


Savariar, E. N.; Kopelman, J.; Thayumanavan, S. “Supramolecular Assemblies from Amphiphilic Dendrons for Sensing Metalloproteins Through Pattern Generation” Israel J. Chem. 2009, 49, 41-47 (Invited article). (DOI: 10.1560/IJC.49.1.41) (S)


Gomez-Escudero, A.; Azagarsamy, M.A.; Theddu, N.; Vachet, R.W.; Thayumanavan, S. “Selective Peptide Binding Using Facially Amphiphilic Dendrimers” J. Am. Chem. Soc. 2008, 130, 11156-11163. (DOI: 10.1021/ja803082v) (S)


Savariar, E. N.; Ghosh, S.; González, D. C.; Thayumanavan, S. “Disassembly of Noncovalent Amphiphilic Polymers with Proteins and Utility in Pattern Sensing” J. Am. Chem. Soc. 2008, 130, 5416-5417.  (DOI: 10.1021/ja800164z) (R, S)


Savariar, E.N.; Krishnamoorthy, K.; Thayumanavan, S. “Molecular Discrimination Inside Polymer Nanotubules” Nature Nanotech. 2008, 3, 112-117. (DOI: 10.1038/nnano.2008.6) (S)


Klaikherd, A.; Ghosh, S.; Thayumanavan, S. “A Facile Method for the Synthesis of Cleavable Block Copolymers from ATRP-based Homopolymers” Macromolecules, 2007, 40, 8518-8520. (DOI: 10.1021/ma071852n) (R, S)


Combariza, Y.; Savariar, E. N.; Vutukuri, D. R; Thayumanavan, S.; Vachet, R. W. “Polymeric Inverse Micelles as Selective Peptide Extraction Agents for MALDI-MS Analysis” Anal. Chem. 2007, 79, 7124-7130. (DOI: 10.1021/ac071001d) (S)


Ambade, A.; Aathimanikandan, S. V.; van der Poll, D.; Thayumanavan, S. “Smaller Building Blocks Form Larger Assemblies: Aggregation Behavior of Biaryl-based Dendritic Facial Amphiphiles” J. Org. Chem. 2007, 72, 8167-8174. (DOI: 10.1021/jo070447r) (S)


Ambade, A.; Chen, Y.; Thayumanavan, S. “”Controlled Functional Group Presentations in Dendrimers as a Tool to Probe the Hyperbranched Architecture” New J. Chem. 2007, 31, 1052-1063 (invited review). (DOI: 10.1039/B617628C) (S)


Sandanaraj, B. S.; Demont, R.; Thayumanavan, S. “Generating Patterns for Sensing Using a Single Receptor Scaffold” J. Am. Chem. Soc. 2007, 129, 3506-3507. (DOI: 10.1021/ja070229f) (S)


Sandanaraj, B. S.; Bayraktar, H.; Krishnamoorthy, K.; Knapp, M. J.; Thayumanavan, S. “Recognition and Modulation of Cytochrome c‘s Redox Properties using an Amphiphilic Homopolymer” Langmuir, 2007, 23, 3891-3897. (DOI: 10.1021/la063063p) (S)


Ambade, A. V.; Savariar, E. N.; Thayumanavan, S. “Dendritic Nanostructures for Cancer Therapy” Nanotechnology for Cancer Therapy, 2007, 509-521. (invited review). (DOI: 10.1201/9781420006636.ch26) (R, S)


Krishnamoorthy, K.; Reddy, D. R.; Nantalaksakul, A.; Thayumanavan, S. “Probing the Periphery of Dendrimers by Heterogeneous Electron Transfer” Chem. Commun. 2007, 739-741. (DOI: 10.1039/B614236B) (S)


Arumugam, S.; Vutukuri, D. R.; Thayumanavan, S.; Ramamurthy, V. “A Styrene Based Water Soluble Polymer as a Reaction Medium for Photodimerization of Aromatic Hydrocarbons in Water” J. Photochem. Photobiol. A: Chem. 2007, 185, 168-171. (DOI: 10.1016/j.jphotochem.2006.05.032) (S)


Ambade, A. V.; Sandanaraj, B. S.; Klaikherd, A.; Thayumanavan, S. “Fluorescent Polyelectrolytes as Protein Sensors” Polymer International, 2007, 56, 474-481 (Invited review). (DOI: 10.1002/pi.2185) (S)


Rotello, V.; Thayumanavan, S. “Editorial (Special issue on ‘Recognition Mediated Self-Assembly of Polymers’)” Polymer International, 2007, 56, 435. (DOI: 10.1002/pi.2288) (S)


Chen, Y.; Vutukuri, D. R.; Ambade, A. V.; Thayumanavan, S. “Self-Assembly of Facially Amphiphilic Dendrimers on Surfaces” J. Am. Chem. Soc. 2006, 128, 14760-14761. (DOI: 10.1021/ja065625x) (S)


Savariar, E. N.; Aathimanikandan, S. V.; Thayumanavan, S. “Supramolecular Assemblies from Amphiphilic Homopolymers: Testing the Scope” J. Am. Chem. Soc. 2006, 128, 16224-16230. (DOI: 10.1021/ja065213o) (S)


Ghosh, S.; Basu, S.; Thayumanavan, S. “Simultaneous and Reversible Functionalization of Copolymers for Biological Applications” Macromolecules, 2006, 39, 5595-5597. (DOI: 10.1021/ma061420x) (R, S)


Roy, R.; Sandanaraj, B. S.; Klaikherd, A.; Thayumanavan, S. “Tuning Substrate Selectivity of a Cationic Enzyme Using Cationic Polymers” Langmuir, 2006, 22, 7695-7700. (DOI: 10.1021/la060496j) (R, S)


Sandanaraj, B. S.; Demont, R.; Aathimanikandan, S. V.; Savariar, E. N.; Thayumanavan, S. “Selective Sensing of Metalloproteins from Non-selective Binding using a Fluorogenic Amphiphilic Polymer” J. Am. Chem. Soc. 2006, 128, 10686-10687. (DOI: 10.1021/ja063544v) (S)


Klaikherd, A.; Sandanaraj, B. S.; Vutukuri, D.; Thayumanavan, S. “Comparison of Facially Amphiphilic Biaryl Dendrimers with Classical Amphiphilic Ones Using Protein Surface Recognition as the Tool” J. Am. Chem. Soc. 2006, 128, 9231-9237. (DOI: 10.1021/ja0622406) (S)


Basu, S.; Vutukuri, D.; Thayumanavan, S. “Homopolymer Micelles in Heterogeneous Solvent Mixtures” J. Am. Chem. Soc. 2005, 127, 16794-16795. (DOI: 10.1021/ja056042a) (S)


Arumugam, S.; Vutukuri, D. R.; Thayumanavan, S.; Ramamurthy, V. “Amphiphilic Homopolymer as a Reaction Medium in Water: Product Selectivity Within Polymeric Nanopockets” J. Am. Chem. Soc. 2005, 127, 13200-13206. (DOI: 10.1021/ja051107v) (S)


Aathimanikandan, S. V.; Savariar, E. N.; Thayumanavan, S. “Temperature-Sensitive Dendritic Micelles” J. Am. Chem. Soc. 2005, 127, 14922-14929. (DOI: 10.1021/ja054542y) (S)


Sandanaraj, B. S.; Vutukuri, D.; Simard, J.; Klaikherd, A.; Hong, R.; Rotello, V. M.; Thayumanavan, S. “Non-Covalent Modification of Chymotrypsin Surface using Amphiphilic Polymeric Scaffold: Implications in Modulating Protein Function” J. Am. Chem. Soc. 2005, 127, 10693-10698. (DOI: 10.1021/ja051947+) (S)


Ambade, A.; Savariar, E. N.; Thayumanavan, S. “Dendrimeric Micelles for Controlled Drug Release and Targeted Delivery” Mol. Pharm. 2005, 2, 264-272 (invited review). (DOI: 10.1021/mp050020d) (S)


Jiang, J.; Thayumanavan, S. “Synthesis and Characterization of Amine-Functionalized Polystyrene Nanoparticles” Macromolecules, 2005, 38, 5886-5891. (DOI: 10.1021/ma0507286) (S, R)


Sivakumar, A. V.; Sandanaraj, B. S.; Arges, C. G.; Bardeen, C. J.; Thayumanavan, S. “Effect of Guest Molecule Flexibility in Access to Dendritic Interiors” Org. Lett. 2005, 7, 2809-2812. (DOI: 10.1021/ol050579b) (S)


Sivanandan, K.; Aathimanikandan, S. V.; Arges, C. G.; Bardeen, C. J.; Thayumanavan, S. “Probing Every Layer in Dendrons” J. Am. Chem. Soc.2005, 127, 2020-2021. (DOI: 10.1021/ja043356+) (S, E)


Jayakumar, K. N.; Thayumanavan, S. “Comparison of AB2 and AB4 Monomers in Ferrocene-cored Benzyl Ether Dendrimers” Tetrahedron, 2005, 61, 603-608. (DOI: 10.1016/j.tet.2004.11.002) (S)


Vutukuri, D. R.; Basu, S.; Thayumanavan, S. “Dendrimers with both Polar and Apolar Nanocontainer Characteristics” J. Am. Chem. Soc. 2004, 126, 15636-15637. (DOI: 10.1021/ja0449628) (S)


Savariar, E. N.; Thayumanavan, S. “Controlled Polymerization of N-isopropylacrylamide with an Activated Methacrylic Ester” J. Poly. Sci. Part A: Poly. Chem. 2004, 42, 6340-6345. (DOI:10.1002/pola.20467) (S, R)


Basu, S.; Vutukuri, D.; Shyamroy, S.; Sandanaraj, B.S.; Thayumanavan, S. “Invertible Amphiphilic Polymers” J. Am. Chem. Soc. 2004, 126, 9890-9891. (DOI: 10.1021/ja047816a) (S, R)


Jayakumar, K. N.; Thayumanavan, S. “Dendrimers Based on a Three-dimensionally Disposed AB4 Monomer” Org. Lett. 2004, 6, 2547-2550. (DOI: 10.1021/ol049147b) (S)


Sivanandan, K.; Britto,S.S.; Thayumanavan, S. “Sequences in Dendrons and Dendrimers” J. Org. Chem. 2004, 69, 2937-2944. (DOI: 10.1021/jo049878p) (S)


Thayumanavan, S.; Bharathi, P.; Sivanandan, K.; Vutukuri, D.R. “Towards Dendrimers as Biomimetic Macromolecules” Comptes Rendus Chimie, 2003, 6, 767-778 (invited review). (DOI: 10.1016/j.crci.2003.08.007) (S)


Vutukuri, D.; Sivanandan, K.; Thayumanavan, S. ” Synthesis of dendrimers with multifunctional periphery using an ABB’ monomer” Chem. Commun. 2003, 796-797. (DOI: 10.1039/B212206P) (S)


Vutukuri, D.; Bharathi, P.; Yu, Z.; Rajasekaran, K.; Tran, M.-H.; Thayumanavan, S. “A Mild Deprotection Strategy for Allyl-Protecting Groups and Its Implications in Sequence Specific Dendrimer Synthesis” J. Org. Chem. 2003, 68, 1146-1149.  (DOI: 10.1021/jo026469p) (S)


Sivanandan, K.; Vutukuri, D.; Thayumanavan, S. “Functional Group Diversity in Dendrimers” Org. Lett. 2002, 4, 3751-3753. (DOI: 10.1021/ol026746e) (S)


Ganesh, R.N.; Shraberg, J.; Sheridan, P.G.; Thayumanavan, S. “Synthesis of Difunctionalized Dendrimers: An Approach to Main Chain Poly(dendrimers)” Tetrahedron Lett. 2002, 43, 7217-7220. (DOI: 10.1016/S0040-4039(02)01656-8) (S)


Bharathi, P.; Zhao, H.; Thayumanavan, S. “Toward Globular Macromolecules with Functionalized Interiors: Design and Synthesis of Dendrons with an Interesting Twist” Org. Lett. 2001, 3, 1961-1964. (DOI: 10.1021/ol016064b) (S)