Supramolecular Assembly and Disassembly

155)

Amado Torres, D.; Garzoni, M.; Subrahmanyam, A.; Pavan, G. M.; Thayumanavan, S. “Protein-Triggered Supramolecular Disassembly: Insights Based on Variations in Ligand Location in Amphiphilic Dendrons” J. Am. Chem. Soc. 2014, 136, In press. (DOI: 10.1021/ja500634u ) (R,S)

155


153)

Guo, J.; Zhuang, J.; Wang, F.; Raghupathi, K.; Thayumanavan, S. “Protein AND Enzyme Gated Supramolecular Disassembly”  J. Am. Chem. Soc. 2014, 136, 2220-2223   (DOI: 10.1021/ja4108676) (R,S). 

153


150)

Zhuang, J.; Chacko, R.; Amado Torres, D.; Wang, H.; Thayumanavan, S. “Dual Stimuli – Dual Response Nanoassemblies Prepared from a Simple Homopolymer” ACS Macro Lett. 2014, 3, 1-5 (DOI: 10.1021/mz400515s) (R,S).

150


149)

Raghupathi, K.; Li, L.; Ventura, J.; Jennings, M.; Thayumanavan, S. “pH Responsive Soft Nanoclusters with Size and Charge Conversional Features” Polymer Chem. 2014, 4, In press. (DOI:10.1039/C3PY01277H) (R,S)

149


148)

Yuan, C.; Raghupathi, K.; Popere, B. C.; Ventura, J.; Dai, L.; Thayumanavan, S. “Composite Supramolecular Nanoassemblies with Independent Stimulus Sensitivities”  Chem. Sci. 2014, 5, 229-234. (DOI:10.1039/C3SC52347K) (R,S)

 

148


147)

Wang, H.; Zhuang, J.; Thayumanavan, S. ““Functionalizable Amine-based Polymer Nanoparticles” ACS Macro Lett. 2013, 2, 948-951. (DOI: 10.1021/mz4004248) (R,S)

147


146)

Wang, F.; Gomez-Escudero, A.; Ramireddy, R. R.; Murage, G.; Thayumanavan, S.; Vachet, R. W. “Electrostatic Control of Peptide Side-Chain Reactivity using Amphiphilic Homopolymer-based Supramolecular Assemblies” J. Am. Chem. Soc. 2013, 135, 14179-14188. (DOI: 10.1021/ja404940s) (S)

146


145)

Ramireddy, R.; Subrahmanyam, A.; Thayumanavan, S. “Zwitterionic Moieties from the Huisgen Reaction-A Case Study with Amphiphilic Dendritic Assemblies” Chem. Eur. J. 2013, 19, In press. (S)145


144)

Li, L.; Raghupathi, K.; Yuan, C.; Thayumanavan, S. “Surface Charge Generation in Nanogels for Activated Cellular Uptake at Tumor-Relevant pH” Chem. Sci. 2013, 4, 3654-3660. (DOI: 10.1039/C3SC50899D) (R,S)144

 


143)

Fuller, J.; Raghupathi, K.; Ramireddy, R. R.; Subrahmanyam, A.; Yesilyurt, V.; Thayumanavan, S. “Temperature-Sensitive Transitions Below LCST in Amphiphilic Dendritic Assemblies – Host-Guest Implications” J. Am. Chem. Soc. 2013, 135, 8947-8954. (DOI: 10.1021/ja402019c) (R,S)


142)

Zhuang, J.; Gordon, M.; Ventura, J.; Li, L. Thayumanavan, S. “Multi-Stimuli Responsive Macromolecules and Their Assemblies” Chem. Soc. Rev. 2013, 42, 7421-7435. (DOI: 10.1039/C3CS60094G) (R, S)


138)

Bickerton, S.; Jiwpanich, S.; Thayumanavan, S. “Interconnected Roles of Scaffold Hydrophobicity, Drug Loading and Encapsulation Stability in Polymeric Nanocarriers” Mol. Pharm. 2012, 9, 3569-3578. (DOI: 1021/mp3004226) (R, S)


137)

Siripornnopakhun, W.; Niamnont, N.; Krumsri, A.; Tumcharern, G.; Vilaivan, T.; Rashatasakhon, P.; Thayumanavan, S.; Sukwattanasinitt, M. “Inclusion Complexes between Amphiphilic Phenylene-Ethynylene Fluorophores and Cyclodextrins in Aqueous Media” J. Phys. Chem. B. 2012, 116, 12268-12274. (DOI: 10.1021/jp3057652) (S)


132)

Amado Torres, D.; Azagarsamy, M.; Thayumanavan, S. “Supramolecular Displacement-Mediated Activation of a Silent Fluorescence Probe for Label-free Ligand Screening” J. Am. Chem. Soc. 2012, 134, 7235-7237. (DOI: 10.1021/ja301204z) (S)


129)

Ramireddy, R.; Raghupathi, K. R.; Torres, D. A.; Thayumanavan, S. “Stimuli Sensitive Amphiphilic Dendrimers” New J. Chem. 2012, 26, 340-349. (Invited Perspective). (DOI: 10.1039/C2NJ20879B) (S)


125)

Rodthongkum, N.; Ramireddy, R.; Thayumanavan, S.; Vachet, R. W. “Selective Enrichment and Sensitive Detection of Peptide and Protein Biomarkers in Human Serum Using Polymeric Reverse Micelles and MALDI-MS” Analyst 2012, 137, 1024-1030. (DOI: 10.1039/C2AN16089G) (S)


123)

Yesilyurt, V.; Ramireddy, R.; Azhagarsamy, M. A.; Thayumanavan, S. “Accessing Lipophilic Ligands in Dendrimer-based Amphiphilic Supramolecular Assemblies for Protein-Induced Disassembly” Chem. Eur. J. 2012, 18, 223-229. (DOI: 10.1002/chem.201102727) (S)


122)

Wang, F.; Klaikherd, A.; Thayumanavan, S. “Temperature Sensitivity Trends and Multi-Stimuli-Sensitive Behavior in Amphiphilic Oligomers” J. Am. Chem. Soc. 2011, 133, 13496-13503. (DOI: 10.1021/ja204121a) (S)


120)

Raghupathi, K. R.; Azagasarmy, M. A.; Thayumanavan, S. “Guest Release Control in Enzyme-Sensitive Amphiphilic Dendrimer-based Nanoparticles through Photochemical Crosslinking” Chem. Eur. J. 2011, 17, 11752-11760. (DOI: 10.1002/chem.201101066) (S)


119)

Nagamani, C.; Viswanathan, U.; Versek, C.; Tuominen, M.; Auerbach, S. M.; Thayumanavan, S. “”Importance of Dynamic Hydrogen Bonds and Reorientation Barriers in Proton Transport” Chem. Commun. 2011, 47, 6638-6640. (DOI: 10.1039/C1CC11207D) (E, S)


117)

Yesilyurt, V.; Ramireddy, R.; Thayumanavan, S. “Photo-Regulated Release of Non-covalent Guests from Dendritic Amphiphilic Nanocontainers” Angew. Chem. It. Ed. 2011, 50, 3038-3042. (DOI: 10.1002/anie.201006193) (S)


114)

Jiwpanich, S.; Ryu, J.-H.; Bickerton, S.; Thayumanavan, S. “Noncovalent Encapsulation Stability in Supramolecular Nanoassemblies” J. Am. Chem. Soc. 2010, 132, 10683-10685. (DOI: 10.1021/ja105059g) (R, S)


113)

Rodthongkum, N.; Chen, Y.; Thayumanavan, S.; Vachet, R. W. “Selective Enrichment and Analysis of Acidic Peptides and Proteins Using Polymeric Reverse Micelles and MALDI-MS” Anal. Chem. 2010, 82, 8686-8691. (DOI: 10.1021/ac101922b) (S)


109)

Rodthongkum, N.; Chen, Y.; Thayumanavan, S.; Vachet, R. W. “MALDI-MS Signal Enhancement of Peptides after Selective Extraction with Polymeric Reverse Micelles” Anal. Chem. 2010, 82, 3686-3691. (DOI: 10.1021/ac1000256) (S)


108)

Azagarsamy, M.; Yesilyurt, V.; Thayumanavan, S. “Disassembly of Dendritic Micellar Containers due to Protein Binding” J. Am. Chem. Soc. 2010, 132, 4550-4551. (DOI: 10.1021/ja100746d) (S)


106)

Chen, Y.; Thorn, M.; Christensen, S.; Versek, C.; Poe, A.; Hayward, R. C.; Tuominen, M. T.; Thayumanavan, S. “Enhancement of Anhydrous Proton Transport by Supramolecular Nanochannels in Comb Polymers” Nature Chem. 2010, 2, 503-508. (DOI: 10.1038/nchem.629) (E, S)


104)

Ryu, J.; Roy, R.; Ventura, J.; Thayumanavan, S. “Redox-Sensitive Disassembly of Amphiphilic Copolymer Based Micelles” Langmuir, 2010, 26, 7086-7092. (DOI: 10.1021/la904437u) (S)


102)

Azagarsamy, M.; Krishnamoorthy, K.; Sivanandan, K.; Thayumanavan, S. “Site-specific Installation and Study of Electroactive Units in Every Layer of Dendrons” J. Org. Chem. 2009, 74, 9475-9485. (DOI: 10.1021/jo902109u) (S)


101)

Azagarsamy, M.; Sokkalingam, P.; Thayumanavan, S. “Enzyme Triggered Disassembly of Dendrimer-based Amphiphilic Nanocontainers” J. Am. Chem. Soc. 2009, 131, 14184-14185. (DOI: 10.1021/ja906162u) (S)


100)

Azagarsamy, M.; Thayumanavan, S. “Magnetic Resonance Imaging: Making Sense of Disassembly” Nature Chemistry, 2009, 1, 523-524. (DOI:10.1038/nchem.383) (S)


98)

Chen, Y.; Thayumanavan, S. “Amphiphilicity in Homopolymer Surfaces Reduces Non-specific Protein Adsorption” Langmuir, 2009, 25, 13795-13799 (Invited manuscript for the 25th year anniversary of Langmuir). (DOI: 10.1021/la901692a) (S)


96)

Rodthongkum, N.; Washington, J. D.; Savariar, E. N.; Thayumanavan, S.; Vachet, R. W. “Generating Peptide Titration-type Curves Using Polymeric Reverse Micelles as Selective Extraction Agents Along with MALDI-MS Detection” Anal. Chem. 2009, 81, 5046-5053. (DOI: 10.1021/ac900661e) (S)


95)

Kale, T.; Klaikherd, A.; Popere, B.; Thayumanavan, S. “Supramolecular Assemblies of Amphiphilic Homopolymers” Langmuir, 2009, 25, 9660-9670 (Invited Feature Article). (DOI:10.1021/la900734d) (S)


94)

González, D. C; Savariar, E. N.; Thayumanavan, S. “Fluorescence Patterns from Supramolecular Polymer Assembly and Disassembly for Sensing of Metallo- and Non-metalloproteins” J. Am. Chem. Soc. 2009, 131, 7708-7716. (DOI: 10.1021/ja900579g) (S)


93)

Azagarsamy, M.A.; Gomez-Escudero, A.; Yesilyurt, V.; Vachet, R.W.; Thayumanavan, S. “Amphiphilic Nanoassemblies for the Detection of Peptides and Proteins Using Fluorescence and Mass Spectrometry” Analyst, 2009, 134, 635-649 (Invited Review). (DOI: 10.1039/B818484D) (S)


90)

Jiwpanich, S.; Sandanararj, B. S.; Thayumanavan, S. “Fluorophore-Cored Dendrimers for Patterns in Metalloprotein Sensing” Chem. Commun. 2009, 806-808. (DOI: 10.1039/B815263B) (S)


88)

Savariar, E. N.; Kopelman, J.; Thayumanavan, S. “Supramolecular Assemblies from Amphiphilic Dendrons for Sensing Metalloproteins Through Pattern Generation” Israel J. Chem. 2009, 49, 41-47 (Invited article). (DOI: 10.1560/IJC.49.1.41) (S)


86)

Gomez-Escudero, A.; Azagarsamy, M.A.; Theddu, N.; Vachet, R.W.; Thayumanavan, S. “Selective Peptide Binding Using Facially Amphiphilic Dendrimers” J. Am. Chem. Soc. 2008, 130, 11156-11163. (DOI: 10.1021/ja803082v) (S)


85)

Savariar, E. N.; Ghosh, S.; González, D. C.; Thayumanavan, S. “Disassembly of Noncovalent Amphiphilic Polymers with Proteins and Utility in Pattern Sensing” J. Am. Chem. Soc. 2008, 130, 5416-5417.  (DOI: 10.1021/ja800164z) (R, S)


84)

Savariar, E.N.; Krishnamoorthy, K.; Thayumanavan, S. “Molecular Discrimination Inside Polymer Nanotubules” Nature Nanotech. 2008, 3, 112-117. (DOI: 10.1038/nnano.2008.6) (S)


83)

Klaikherd, A.; Ghosh, S.; Thayumanavan, S. “A Facile Method for the Synthesis of Cleavable Block Copolymers from ATRP-based Homopolymers” Macromolecules, 2007, 40, 8518-8520. (DOI: 10.1021/ma071852n) (R, S)


82)

Combariza, Y.; Savariar, E. N.; Vutukuri, D. R; Thayumanavan, S.; Vachet, R. W. “Polymeric Inverse Micelles as Selective Peptide Extraction Agents for MALDI-MS Analysis” Anal. Chem. 2007, 79, 7124-7130. (DOI: 10.1021/ac071001d) (S)


81)

Ambade, A.; Aathimanikandan, S. V.; van der Poll, D.; Thayumanavan, S. “Smaller Building Blocks Form Larger Assemblies: Aggregation Behavior of Biaryl-based Dendritic Facial Amphiphiles” J. Org. Chem. 2007, 72, 8167-8174. (DOI: 10.1021/jo070447r) (S)


78)

Ambade, A.; Chen, Y.; Thayumanavan, S. “”Controlled Functional Group Presentations in Dendrimers as a Tool to Probe the Hyperbranched Architecture” New J. Chem. 2007, 31, 1052-1063 (invited review). (DOI: 10.1039/B617628C) (S)


77)

Sandanaraj, B. S.; Demont, R.; Thayumanavan, S. “Generating Patterns for Sensing Using a Single Receptor Scaffold” J. Am. Chem. Soc. 2007, 129, 3506-3507. (DOI: 10.1021/ja070229f) (S)


76)

Sandanaraj, B. S.; Bayraktar, H.; Krishnamoorthy, K.; Knapp, M. J.; Thayumanavan, S. “Recognition and Modulation of Cytochrome c‘s Redox Properties using an Amphiphilic Homopolymer” Langmuir, 2007, 23, 3891-3897. (DOI: 10.1021/la063063p) (S)


75)

Ambade, A. V.; Savariar, E. N.; Thayumanavan, S. “Dendritic Nanostructures for Cancer Therapy” Nanotechnology for Cancer Therapy, 2007, 509-521. (invited review). (DOI: 10.1201/9781420006636.ch26) (R, S)


74)

Krishnamoorthy, K.; Reddy, D. R.; Nantalaksakul, A.; Thayumanavan, S. “Probing the Periphery of Dendrimers by Heterogeneous Electron Transfer” Chem. Commun. 2007, 739-741. (DOI: 10.1039/B614236B) (S)


73)

Arumugam, S.; Vutukuri, D. R.; Thayumanavan, S.; Ramamurthy, V. “A Styrene Based Water Soluble Polymer as a Reaction Medium for Photodimerization of Aromatic Hydrocarbons in Water” J. Photochem. Photobiol. A: Chem. 2007, 185, 168-171. (DOI: 10.1016/j.jphotochem.2006.05.032) (S)


72)

Ambade, A. V.; Sandanaraj, B. S.; Klaikherd, A.; Thayumanavan, S. “Fluorescent Polyelectrolytes as Protein Sensors” Polymer International, 2007, 56, 474-481 (Invited review). (DOI: 10.1002/pi.2185) (S)


71)

Rotello, V.; Thayumanavan, S. “Editorial (Special issue on ‘Recognition Mediated Self-Assembly of Polymers’)” Polymer International, 2007, 56, 435. (DOI: 10.1002/pi.2288) (S)


70)

Chen, Y.; Vutukuri, D. R.; Ambade, A. V.; Thayumanavan, S. “Self-Assembly of Facially Amphiphilic Dendrimers on Surfaces” J. Am. Chem. Soc. 2006, 128, 14760-14761. (DOI: 10.1021/ja065625x) (S)


69)

Savariar, E. N.; Aathimanikandan, S. V.; Thayumanavan, S. “Supramolecular Assemblies from Amphiphilic Homopolymers: Testing the Scope” J. Am. Chem. Soc. 2006, 128, 16224-16230. (DOI: 10.1021/ja065213o) (S)


67)

Ghosh, S.; Basu, S.; Thayumanavan, S. “Simultaneous and Reversible Functionalization of Copolymers for Biological Applications” Macromolecules, 2006, 39, 5595-5597. (DOI: 10.1021/ma061420x) (R, S)


66)

Roy, R.; Sandanaraj, B. S.; Klaikherd, A.; Thayumanavan, S. “Tuning Substrate Selectivity of a Cationic Enzyme Using Cationic Polymers” Langmuir, 2006, 22, 7695-7700. (DOI: 10.1021/la060496j) (R, S)


65)

Sandanaraj, B. S.; Demont, R.; Aathimanikandan, S. V.; Savariar, E. N.; Thayumanavan, S. “Selective Sensing of Metalloproteins from Non-selective Binding using a Fluorogenic Amphiphilic Polymer” J. Am. Chem. Soc. 2006, 128, 10686-10687. (DOI: 10.1021/ja063544v) (S)


63)

Klaikherd, A.; Sandanaraj, B. S.; Vutukuri, D.; Thayumanavan, S. “Comparison of Facially Amphiphilic Biaryl Dendrimers with Classical Amphiphilic Ones Using Protein Surface Recognition as the Tool” J. Am. Chem. Soc. 2006, 128, 9231-9237. (DOI: 10.1021/ja0622406) (S)


60)

Basu, S.; Vutukuri, D.; Thayumanavan, S. “Homopolymer Micelles in Heterogeneous Solvent Mixtures” J. Am. Chem. Soc. 2005, 127, 16794-16795. (DOI: 10.1021/ja056042a) (S)


57)

Arumugam, S.; Vutukuri, D. R.; Thayumanavan, S.; Ramamurthy, V. “Amphiphilic Homopolymer as a Reaction Medium in Water: Product Selectivity Within Polymeric Nanopockets” J. Am. Chem. Soc. 2005, 127, 13200-13206. (DOI: 10.1021/ja051107v) (S)


56)

Aathimanikandan, S. V.; Savariar, E. N.; Thayumanavan, S. “Temperature-Sensitive Dendritic Micelles” J. Am. Chem. Soc. 2005, 127, 14922-14929. (DOI: 10.1021/ja054542y) (S)


55)

Sandanaraj, B. S.; Vutukuri, D.; Simard, J.; Klaikherd, A.; Hong, R.; Rotello, V. M.; Thayumanavan, S. “Non-Covalent Modification of Chymotrypsin Surface using Amphiphilic Polymeric Scaffold: Implications in Modulating Protein Function” J. Am. Chem. Soc. 2005, 127, 10693-10698. (DOI: 10.1021/ja051947+) (S)


54)

Ambade, A.; Savariar, E. N.; Thayumanavan, S. “Dendrimeric Micelles for Controlled Drug Release and Targeted Delivery” Mol. Pharm. 2005, 2, 264-272 (invited review). (DOI: 10.1021/mp050020d) (S)


53)

Jiang, J.; Thayumanavan, S. “Synthesis and Characterization of Amine-Functionalized Polystyrene Nanoparticles” Macromolecules, 2005, 38, 5886-5891. (DOI: 10.1021/ma0507286) (S, R)


52)

Sivakumar, A. V.; Sandanaraj, B. S.; Arges, C. G.; Bardeen, C. J.; Thayumanavan, S. “Effect of Guest Molecule Flexibility in Access to Dendritic Interiors” Org. Lett. 2005, 7, 2809-2812. (DOI: 10.1021/ol050579b) (S)


51)

Sivanandan, K.; Aathimanikandan, S. V.; Arges, C. G.; Bardeen, C. J.; Thayumanavan, S. “Probing Every Layer in Dendrons” J. Am. Chem. Soc.2005, 127, 2020-2021. (DOI: 10.1021/ja043356+) (S, E)


49)

Jayakumar, K. N.; Thayumanavan, S. “Comparison of AB2 and AB4 Monomers in Ferrocene-cored Benzyl Ether Dendrimers” Tetrahedron, 2005, 61, 603-608. (DOI: 10.1016/j.tet.2004.11.002) (S)


48)

Vutukuri, D. R.; Basu, S.; Thayumanavan, S. “Dendrimers with both Polar and Apolar Nanocontainer Characteristics” J. Am. Chem. Soc. 2004, 126, 15636-15637. (DOI: 10.1021/ja0449628) (S)


47)

Savariar, E. N.; Thayumanavan, S. “Controlled Polymerization of N-isopropylacrylamide with an Activated Methacrylic Ester” J. Poly. Sci. Part A: Poly. Chem. 2004, 42, 6340-6345. (DOI:10.1002/pola.20467) (S, R)


46)

Basu, S.; Vutukuri, D.; Shyamroy, S.; Sandanaraj, B.S.; Thayumanavan, S. “Invertible Amphiphilic Polymers” J. Am. Chem. Soc. 2004, 126, 9890-9891. (DOI: 10.1021/ja047816a) (S, R)


45)

Jayakumar, K. N.; Thayumanavan, S. “Dendrimers Based on a Three-dimensionally Disposed AB4 Monomer” Org. Lett. 2004, 6, 2547-2550. (DOI: 10.1021/ol049147b) (S)


44)

Sivanandan, K.; Britto,S.S.; Thayumanavan, S. “Sequences in Dendrons and Dendrimers” J. Org. Chem. 2004, 69, 2937-2944. (DOI: 10.1021/jo049878p) (S)


43)

Thayumanavan, S.; Bharathi, P.; Sivanandan, K.; Vutukuri, D.R. “Towards Dendrimers as Biomimetic Macromolecules” Comptes Rendus Chimie, 2003, 6, 767-778 (invited review). (DOI: 10.1016/j.crci.2003.08.007) (S)


41)

Vutukuri, D.; Sivanandan, K.; Thayumanavan, S. ” Synthesis of dendrimers with multifunctional periphery using an ABB’ monomer” Chem. Commun. 2003, 796-797. (DOI: 10.1039/B212206P) (S)


40)

Vutukuri, D.; Bharathi, P.; Yu, Z.; Rajasekaran, K.; Tran, M.-H.; Thayumanavan, S. “A Mild Deprotection Strategy for Allyl-Protecting Groups and Its Implications in Sequence Specific Dendrimer Synthesis” J. Org. Chem. 2003, 68, 1146-1149.  (DOI: 10.1021/jo026469p) (S)


39)

Sivanandan, K.; Vutukuri, D.; Thayumanavan, S. “Functional Group Diversity in Dendrimers” Org. Lett. 2002, 4, 3751-3753. (DOI: 10.1021/ol026746e) (S)


38)

Ganesh, R.N.; Shraberg, J.; Sheridan, P.G.; Thayumanavan, S. “Synthesis of Difunctionalized Dendrimers: An Approach to Main Chain Poly(dendrimers)” Tetrahedron Lett. 2002, 43, 7217-7220. (DOI: 10.1016/S0040-4039(02)01656-8) (S)


36)

Bharathi, P.; Zhao, H.; Thayumanavan, S. “Toward Globular Macromolecules with Functionalized Interiors: Design and Synthesis of Dendrons with an Interesting Twist” Org. Lett. 2001, 3, 1961-1964. (DOI: 10.1021/ol016064b) (S)